Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.

Gastroenterology
Lei ZhangDavid T W Wong

Abstract

Lack of detection technology for early pancreatic cancer invariably leads to a typical clinical presentation of incurable disease at initial diagnosis. New strategies and biomarkers for early detection are sorely needed. In this study, we have conducted a prospective sample collection and retrospective blinded validation to evaluate the performance and translational utilities of salivary transcriptomic biomarkers for the noninvasive detection of resectable pancreatic cancer. The Affymetrix HG U133 Plus 2.0 Array (Affymetrix, Santa Clara, CA) was used to profile transcriptomes and discover altered gene expression in saliva supernatant. Biomarkers discovered from the microarray study were subjected to clinical validation using an independent sample set of 30 pancreatic cancer patients, 30 chronic pancreatitis patients, and 30 healthy controls. Twelve messenger RNA biomarkers were discovered and validated. The logistic regression model with the combination of 4 messenger RNA biomarkers (KRAS, MBD3L2, ACRV1, and DPM1) could differentiate pancreatic cancer patients from noncancer subjects (chronic pancreatitis and healthy control), yielding a receiver operating characteristic plot, area under the curve value of 0.971 with 90.0% sens...Continue Reading

References

May 1, 1989·Annals of Internal Medicine·D K PleskowD K Podolsky
Aug 30, 2000·Journal of Surgical Oncology·M GogginsR Hruban
May 24, 2001·Journal of Bacteriology·B J PasterF E Dewhirst
Aug 8, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Lenora R BiglerSteven A Bigler
Jan 9, 2003·Gastrointestinal Endoscopy·Stephen J RulyakTeresa A Brentnall
May 6, 2003·Gastroenterology·Stephen J RulyakTeresa A Brentnall
Jan 21, 2004·Journal of Gastroenterology and Hepatology·Jee-Eun KimKyoo Wan Choi
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Feb 26, 2004·Journal of Dental Research·Y LiD T W Wong
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marcia Irene CantoRalph H Hruban
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·David C Whitcomb
Sep 10, 2004·The Journal of Biological Chemistry·Fumiaki OkaharaTomohiko Maehama
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yang LiDavid T Wong
Nov 18, 2005·Forensic Science International : Synergy·Christa NussbaumerIrina Korschineck
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yang LiDavid T Wong
Apr 8, 2006·Clinical Chemistry·Noh Jin ParkDavid T Wong
May 10, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marcia Irene CantoAnthony N Kalloo
Oct 3, 2006·Cancer Biology & Therapy·Carmelle D RogersMichael Goggins
Oct 21, 2006·Archives of Oral Biology·Noh Jin ParkDavid T Wong
Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
Nov 3, 2006·The New England Journal of Medicine·Robert L Goldenberg, Jennifer F Culhane
Dec 13, 2006·Nature Biotechnology·Ron Edgar, Tanya Barrett
Jan 18, 2007·Journal of the National Cancer Institute·Dominique S MichaudCharles S Fuchs
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jack Ballantyne
Jul 28, 2007·Cell Death and Differentiation·J-H YimJ-H Park
Oct 31, 2007·Arthritis and Rheumatism·Shen HuDavid T Wong
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shen HuDavid T Wong
Oct 9, 2008·Journal of the National Cancer Institute·Margaret S PepeJohn D Potter
Nov 29, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D PrezaB J Paster
Dec 17, 2008·World Journal of Surgery·Matthew A FirpoSean J Mulvihill

❮ Previous
Next ❯

Citations

Jul 28, 2011·Neonatology·Jessica A DietzJill L Maron
Sep 16, 2011·Advances in Dental Research·B J BaumJ E Melvin
Sep 16, 2011·Journal of Dental Research·K ThomadakiF G Oppenheim
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Nov 2, 2012·Genome Medicine·Nicolai J Bonne, David Tw Wong
Oct 20, 2010·International Journal of Molecular Sciences·Martha E Arellano-GarciaShen Hu
Jan 11, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·J Romano-KeelerJ L Maron
Jan 11, 2014·Omics : a Journal of Integrative Biology·Betzaida Cuevas-Córdoba, Juan Santiago-García
Oct 9, 2014·Advances in Surgery·Katherine E PorukSean J Mulvihill
May 3, 2014·Seminars in Cancer Biology·Jasmina S RedzicXandra O Breakefield
Apr 26, 2011·Cancer Epidemiology·Georgios TzimagiorgisSofia Kouidou
Oct 16, 2014·American Journal of Respiratory and Critical Care Medicine·Fang WeiDavid T W Wong
Jul 31, 2012·International Journal of Pediatrics·Jill L Maron
Jul 14, 2012·Operative Dentistry·D T W Wong
Jun 13, 2012·Cellular and Molecular Life Sciences : CMLS·Lei ZhangDavid T W Wong
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Umashankar K Ballehaninna, Ronald S Chamberlain
May 17, 2013·Metabolomics : Official Journal of the Metabolomic Society·Alexander Benedikt LeichtleGeorg Martin Fiedler
Nov 19, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yu-Hsiang LeeDavid T Wong
Dec 15, 2015·Periodontology 2000·Dina L Korte, Janet Kinney
Dec 15, 2015·Periodontology 2000·Yong ZhangDavid T W Wong
Nov 7, 2014·Expert Review of Gastroenterology & Hepatology·Claire JenkinsonEithne Costello
Apr 22, 2015·International Journal of Molecular Sciences·Blanca MajemDavid T Wong
Sep 24, 2015·Expert Review of Molecular Diagnostics·Aoife S Crawley, Richard J O'Kennedy
Jan 1, 2011·Expert Opinion on Medical Diagnostics·Ole BrinkmannDavid T Wong
Jan 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nha LeUNKNOWN GEMS collaborating group of Pancreas 2000
Sep 10, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qihui WangYixiang Duan
Nov 20, 2014·Journal of Translational Medicine·Dongmei ChenQingge Li
Mar 8, 2016·Biosensors & Bioelectronics·Saswat MishraWoon-Hong Yeo
Oct 10, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Shang-Long LiuTai-Ping Zhang
Apr 8, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shin Hamada, Tooru Shimosegawa
Jul 20, 2010·Oral Oncology·Ibrahim O BelloTuula Salo
Sep 11, 2013·Biotechnology Journal·Suveen KumarBansi D Malhotra
Dec 3, 2010·Oral Diseases·N Spielmann, D T Wong
May 5, 2016·Disease Markers·Stepan PodzimekZdenek Broukal
Jun 9, 2015·Cancer Science·Dan-dan YuJian-hua Zhao

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