PMID: 3768737Aug 1, 1986Paper

Salivation mediated by central M-2 muscarinic receptors in the cat

Brain Research Bulletin
N Tomic-Beleslin, D B Beleslin

Abstract

In these experiments the effect on the cat's salivation of the choline ester, carbachol, the anticholinesterase, eserine, and the muscarinic ganglionic stimulants, McN-A-343 and AHR-602, injected into the cerebral ventricles was investigated and compared. Carbachol and eserine injected intracerebroventricularly (ICV) produced dose-related salivation. On the other hand, ICV McN-A-343 and AHR-602 evoked inconsistent salivation when injected in large doses. The antimuscarinic drug, atropine, injected into the cerebral ventricles abolished the salivation caused by carbachol and eserine similarly injected. However, salivation induced by ICV carbachol and eserine was not significantly altered by the ganglionic blocking agent, mecamylamine, injected into the cerebral ventricles. It is concluded that the ICV injection of carbachol and eserine evokes salivation in the cat by way of an action on central M-2 muscarinic receptors.

References

Dec 28, 1977·Psychopharmacology·D B Beleslin, R Samardzić
Sep 28, 1954·The Journal of Physiology·W FELDBERG, S L SHERWOOD
Mar 1, 1964·Canadian Journal of Psychology·R D MYERS

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Citations

Mar 1, 1987·Brain Research Bulletin·D B BeleslinN Tomic-Beleslin
Feb 1, 1990·The Journal of Comparative Neurology·D A RuggieroD J Reis
May 31, 2012·Pharmacology & Therapeutics·Frederick J Mitchelson

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