SALL4 is a new target in endometrial cancer

Oncogene
Ailing LiLi Chai

Abstract

Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature. Identifying the key factors/pathway(s) within this ES signature responsible for the aggressiveness of cancers can lead to a potential cure. In this study, we find that SALL4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47.7% of primary human endometrial cancer samples. It is not expressed in normal or hyperplastic endometrial. More importantly, SALL4 expression is positively correlated with worse patient survival and aggressive features such as metastasis in endometrial carcinoma. Further functional studies have shown that loss of SALL4 inhibits endometrial cancer cell growth in vitro and tumorigenicity in vivo, as a result of inhibition of cell proliferation and increased apoptosis. In addition, downregulation of SALL4 significantly impedes the migration and invasion properties of endometrial cancer cells in vitro and their metastatic potential in vivo. Furthermore, manipulation of SALL4 expression can affect drug sensitivity of endometrial cancer cells to carboplatin. Moreover, we show that SALL4 specifically binds to the c-Myc promoter region in endometrial cancer cells. While downregulation o...Continue Reading

References

Sep 1, 1990·Gynecologic Oncology·M P BorstD M Miller
Oct 6, 2000·Endocrine-related Cancer·D J Liao, R B Dickson
Jan 22, 2002·Current Opinion in Obstetrics & Gynecology·Laurie Elit, Hal Hirte
May 29, 2003·Current Cancer Drug Targets·Heiko Hermeking
Dec 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth J RenaudPatricia K Donahoe
Aug 9, 2005·Lancet·Frederic AmantIgnace Vergote
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Jul 15, 2006·The Journal of Biological Chemistry·Qiang WuHuck-Hui Ng
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ulrich EllingMathias Treier
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jianchang YangYupo Ma
Apr 22, 2008·Gynecologic Oncology·Jason Y Y WongImmaculata De Vivo
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianchang YangYupo Ma
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anita WolferSridhar Ramaswamy
Jul 8, 2011·BMJ : British Medical Journal·Srdjan SasoSadaf Ghaem-Maghami
Sep 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yi-Chieh Nancy DuHarold Varmus
Jun 14, 2013·The New England Journal of Medicine·Kol Jia YongDaniel G Tenen

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Citations

Jan 19, 2016·Journal of Molecular Histology·Liliang HaoQi Su
Sep 12, 2015·Journal of Cellular Physiology·Maurizio RomanoUmberto Cillo
Aug 1, 2015·Cancer Metastasis Reviews·Maria João CarvalhoCarlos Freire Oliveira
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ebubekir Dirican, Mustafa Akkiprik
Jun 3, 2016·Histopathology·Shengmei ZhouLarry Wang
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Ping ChenYu Li
May 31, 2019·Molecular & Cellular Proteomics : MCP·Sara R SavageBing Zhang
Apr 3, 2020·Cellular Oncology (Dordrecht)·Kiyoshi MisawaHiroyuki Mineta
Feb 6, 2017·Oncotarget·Lorenzo NicolèAmbrogio Fassina
Oct 6, 2016·Oncotarget·Kol Jia YongLi Chai
Aug 22, 2018·Oncology Letters·Xuefeng Jiang, Zhe Wang
Aug 25, 2020·Molecular Carcinogenesis·Teng ChenLarry M C Chow
Oct 18, 2016·International Journal of Molecular Medicine·Yu ZhouYugang Jiang
Jan 1, 2014·Molecular & Cellular Oncology·Fei WangLi Chai
Aug 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oluwole FadareHussain Abubakr
Jun 7, 2017·Cancer Biomarkers : Section a of Disease Markers·Hongyu ShenJinhai Tang
Apr 11, 2018·Oncoimmunology·Marie KroemerChristophe Borg
Aug 28, 2019·International Journal of Molecular Sciences·Hsing-Ju Wu, Pei-Yi Chu
Jun 4, 2020·Cancer Cell International·Meng ShaoXu Zhang
Dec 15, 2020·Technology in Cancer Research & Treatment·Chong LiuHang Chen
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Yang YangJiafu Ji
Jul 9, 2021·Frontiers in Endocrinology·Umair Ali Khan SaddozaiXiangqian Guo
Oct 2, 2021·Science Advances·Junsu KwonDaniel G Tenen

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Datasets Mentioned

BETA
GSE21882

Methods Mentioned

BETA
transgenic
light microscopy
flow cytometry
xenograft
immunoprecipitation
ChIP-chip
Protein Assay
PCR
pulldown

Software Mentioned

GESA
GSEA
Gene Set Enrichment Analysis ( GSEA )
GraphPad Prism

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