SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

Oncotarget
Gang DengTao Wan

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the most common and deadly disease of the biliary tree due to its poor prognosis. Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). In our study, 175 ICC cases with an average age of 55 years were included, and 53% (93/175) were male. And 28 adjacent non-tumor tissues were also collected. The SALL4-positive immunoreactivity was detected in a total of 102 ICC cases (58%), whereas all 28 adjacent tissues showed negative staining. Univariate analysis, showed that the SALL4-positive ICC cases had significantly more frequent lymph nodal metastasis (P = 0.0460), vascular invasion (P < 0.0001), and nerve invasion (P < 0.0001). Furthermore, the strong SALL4-positive cases (n = 7, 5 months) had shorter overall survival, when compared to moderate SALL4-positive (n = 46, 9 months) or SALL4-negative cases (n = 73, 7 months), respectively. Our data also suggest that SALL4 may be involved in the regulation of epithelial-mesenchymal transition (EMT) in ICC. Those results for the first time indicate an oncogenic role of SALL4 in ICC. Therefore, SALL4 may serve as a promising therapeutic target for ICC.

References

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Citations

Jun 3, 2016·Histopathology·Shengmei ZhouLarry Wang
Jul 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Bee Hui LiuDaniel G Tenen
Dec 26, 2015·Journal of Clinical Medicine·Simone BrivioMario Strazzabosco
Dec 30, 2017·Experimental and Therapeutic Medicine·Botao JiangYaxiong Nie
Feb 6, 2017·Oncotarget·Lorenzo NicolèAmbrogio Fassina
May 4, 2017·World Journal of Gastroenterology : WJG·Christian MayrTobias Kiesslich
Dec 7, 2018·Journal of Cellular Biochemistry·Amireza HesariFaezeh Ghasemi
Oct 27, 2017·Gene Expression·Simone BrivioMario Strazzabosco

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Methods Mentioned

BETA
transfection
ELISA

Software Mentioned

Image
Graphpad Prism
Pro plus
SPSS

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