Sally-Anne test and regional cerebral blood flow in Alzheimer's disease dementia

Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society
Shintaro TakenoshitaSeishi Terada

Abstract

It was recently reported that theory of mind is disturbed in mild Alzheimer's disease dementia (ADD). Some studies have reported reduced scores of ADD patients on false belief tests, even on first-order false belief tests. However, few studies have pursued the neural substrate of false belief tests in patients with ADD in a real-world setting. Sixty-three patients with ADD from outpatient units took the Sally-Anne test and underwent brain single-photon emission computed tomography. Of these patients, 29 answered the Sally-Anne test correctly (successful group) and 34 incorrectly (unsuccessful group). We compared the regional cerebral blood flow between the successful and unsuccessful groups. A comparison of the two groups showed a significantly lower uptake in the bilateral posterior cingulate gyrus in the unsuccessful group than in the successful group. The posterior cingulate gyrus is known to be particularly activated when individuals remember personal events and infer the mental states of others. We suppose that memory or mentalization in the posterior cingulate gyrus-or both-is essential for patients with ADD to be able to pass the Sally-Anne test.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1991·Journal of Geriatric Psychiatry and Neurology·W J BurkeS P Wengel
Oct 1, 1985·Cognition·S Baron-CohenU Frith
May 1, 1982·Journal of Gerontology·R I PfefferS Filos
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Dec 31, 1997·Psychiatry and Clinical Neurosciences·Y AraiS Hisamichi
Dec 13, 2000·Neurology·B DuboisB Pillon
Aug 2, 2001·Child Development·S M Carlson, L J Moses
Aug 3, 2001·Nature Reviews. Neuroscience·S J Blakemore, J Decety
Sep 1, 1996·History of Psychiatry·C W Mac Arthur, R Porter
Aug 23, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Eva ElghLars Nyberg
Nov 5, 2003·The American Journal of Psychiatry·Chadi CalargeDaniel S O'Leary
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Dec 26, 2006·Trends in Cognitive Sciences·Randy L Buckner, Daniel C Carroll
Jun 30, 2007·Psychiatry Research·Aki KugoShigetoshi Kuroda
Nov 24, 2007·Science·R Shayna RosenbaumEndel Tulving
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Dec 9, 2010·Aging & Mental Health·Ilaria CastelliRaffello Nemni
Jan 5, 2011·Annals of Neurology·Olivier GodefroyUNKNOWN Groupe de Réflexion sur l'Evaluation des Fonctions Exécutives Study Group
Dec 14, 2011·Journal of Alzheimer's Disease : JAD·Francesca BaglioAntonella Marchetti
Oct 16, 2012·Brain : a Journal of Neurology·Raphaël Le BoucFlorence Pasquier
Jul 23, 2013·Brain : a Journal of Neurology·Robert Leech, David J Sharp
Feb 4, 2014·Neuroscience and Biobehavioral Reviews·Matthias SchurzJosef Perner
Apr 5, 2014·Aging & Mental Health·Mélanie SandozMarion Fossard
Jan 18, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Emre BoraDennis Velakoulis
Nov 3, 2016·International Journal of Language & Communication Disorders·Terhi KorkiakangasEija Kärnä
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Shintaro TakenoshitaNorihito Yamada

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Citations

Nov 17, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Satoshi HayashiNorihito Yamada

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