PMID: 7515420Jan 1, 1994Paper

Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells

The Journal of Pharmacy and Pharmacology
G GentiliniL Zilletti

Abstract

Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.

References

Sep 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L ZillettiG Gentilini
Nov 1, 1991·British Journal of Pharmacology·P R ButchersM Johnson
Dec 1, 1990·Lancet·O P TwentymanS T Holgate
Jun 24, 1961·Biochimica Et Biophysica Acta·L T KREMZNER, I B WILSON

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