PMID: 8958892Nov 1, 1996Paper

Salmeterol tachyphylaxis in steroid treated asthmatic subjects

Thorax
H BoothE H Walters

Abstract

Tachyphylaxis to the protection afforded by salmeterol to broncho-constrictor stimuli after regular use has been described in patients with mild asthma not receiving inhaled corticosteroids. The present study was performed to investigate whether airway tachyphylaxis occurs in symptomatic asthmatic subjects receiving inhaled corticosteroids, the group for whom salmeterol is recommended in clinical practice. Thirty one adult patients with symptomatic chronic asthma who were receiving inhaled corticosteroids were randomised in a double blind manner and on a 2:1 basis to receive salmeterol 50 micrograms (n = 22) or placebo (n = 9) twice daily. Baseline forced expiratory volume in one second (FEV1) was measured during the run-in period, on day 0, and after four and eight weeks of regular treatment (following a 36 hour test drug washout period). Airway responsiveness to methacholine was measured one hour after administration of the test drug on these occasions. Diary cards were kept throughout the study and for a two week follow up period. Baseline FEV1 was not significantly different between the treatment groups or between visits. There was significant bronchodilatation one hour after salmeterol administration at 0, four, and eight ...Continue Reading

References

Aug 20, 1977·Lancet·S T HolgateA E Tattersfield
Oct 22, 1992·The New England Journal of Medicine·B J O'ConnorP J Barnes
Nov 12, 1992·The New England Journal of Medicine·D S PearlmanS W Yancey
Jul 1, 1994·The American Journal of Medicine·D M NewnhamB J Lipworth
Oct 2, 1993·Lancet·D W CockcroftB C Rutherford
Mar 1, 1993·American Journal of Respiratory Cell and Molecular Biology·E ReihsausS B Liggett

❮ Previous
Next ❯

Citations

May 17, 2003·Pulmonary Pharmacology & Therapeutics·A van VeenR E Jonkers
Sep 19, 2002·British Journal of Clinical Pharmacology·Brian J Lipworth
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Osamu NishiyamaKaoru Shimokata
Jun 17, 2000·Thorax·D R Taylor, R J Hancox
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·K S TanB J Lipworth
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·D A TaylorB J O'Connor
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·D CheungP J Sterk
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·H S NelsonS W Yancey
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·M PalmqvistJ Lötvall
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·X LiE Haydn Walters
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·J C Kips, R A Pauwels
Dec 17, 2009·Therapeutics and Clinical Risk Management·James P Kemp
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·R J Hancox, D R Taylor
May 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B J Lipworth
Apr 29, 1998·Chest·R H MooreB F Dickey
Jun 24, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert B FogelPeter G Polos
Apr 7, 2005·Fundamental & Clinical Pharmacology·P O GirodetM Molimard
Sep 2, 2009·British Journal of Pharmacology·Steven J Charlton
Jan 22, 2011·British Journal of Pharmacology·Scott E EvansBurton F Dickey
Sep 4, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·W D CarrollW Lenney
Jun 17, 1998·The American Journal of Medicine·B LipworthD Hendrick
Dec 15, 2010·The Physician and Sportsmedicine·David T MillwardMark A Brown
Aug 26, 1998·Respiratory Medicine·A A Verberne, R Fuller
Nov 6, 2004·Respiratory Medicine·William StormsUNKNOWN Challenge-Rescue Study Group
Mar 15, 2005·Respiratory Medicine·J A E WaltersE H Walters
Nov 26, 2015·PloS One·John M KnightDavid B Corry
Feb 20, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Donghwa KimStephen B Liggett
Sep 8, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Milind P SovaniAnne E Tattersfield
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Michael J AbramsonE Haydn Walters
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Hanneke J van der Woude, René Aalbers
Jul 23, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·George Bensch, Bruce M Prenner
Mar 9, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Catherine M Jackson, Brian Lipworth
Dec 21, 2004·Treatments in Respiratory Medicine·K Fan Chung, Ian M Adcock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.