Abstract
Although theophylline is recommended by current guidelines for the management of asthma in patients with persistent symptoms, theophylline has a narrow therapeutic index, requiring individual dose titration and regular monitoring of serum theophylline concentrations to avoid adverse effects. To compare the inhaled long-acting bronchodilator, salmeterol, with the oral bronchodilator, theophylline, in the maintenance treatment of asthma. In two multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group studies, patients received salmeterol aerosol 42 micrograms, extended-release theophylline capsules, or placebo twice daily for 12 weeks. Of 638 adult and adolescent patients with moderate asthma who entered the prebaseline theophylline titration period, 154 were withdrawn prior to randomization (71 due to theophylline-related adverse effects); 484 patients comprised the intent-to-treat population. The mean serum theophylline concentration measured approximately seven hours postdose during the titration period in the theophylline group was 12.7 mg/L (70 mumol/L). The same dose during the treatment period resulted in a mean serum theophylline concentration between 7.6 to 7.9 mg/L (42-44 mumol/L) when mea...Continue Reading
References
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·W W StormsC W Zwillich
Nov 12, 1992·The New England Journal of Medicine·D S PearlmanS W Yancey
Oct 1, 1992·Allergy·J LötvallN Svedmyr
Dec 15, 1990·BMJ : British Medical Journal·M F FitzpatrickN J Douglas
Mar 1, 1990·The Journal of Allergy and Clinical Immunology·W E PiersonD Tinkelman
Apr 7, 1990·BMJ : British Medical Journal·I D Johnston
Jun 1, 1986·The Journal of Allergy and Clinical Immunology·H S Nelson
Jul 1, 1987·The American Review of Respiratory Disease
Jan 1, 1986·European Journal of Clinical Pharmacology·F P Maesen, J J Smeets
Mar 1, 1984·British Journal of Clinical Pharmacology·P D DaviesI A Campbell
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R L WilliamsA Bostrom
Sep 1, 1994·Respiratory Medicine·L FjellbirkelandJ B Palmer
Citations
Jun 27, 2000·International Journal of Pharmaceutics·Y MichaelS Gray
Jun 1, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Feb 25, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R A Nathan
Mar 27, 2001·Family Practice·M EcclesUNKNOWN North of England Asthma Guideline Development Group
May 31, 2001·The Western Journal of Medicine·H Kalister
Jun 5, 2003·Postgraduate Medical Journal·R H GreenA J Wardlaw
Jul 22, 1999·Thorax·M CazzolaM G Matera
Feb 12, 2002·Pharmacotherapy·Stuart StoloffPaul M Dorinsky
May 2, 2008·Drugs & Aging·Preeti Gupta, M Sinead O'Mahony
Apr 29, 2005·Journal of Women's Health·Scott L Osur
Dec 8, 2009·American Journal of Obstetrics and Gynecology·Frank R WitterSusan L Connors
Jul 12, 2003·Respiratory Medicine·G LiccardiG Passalacqua
Apr 11, 2001·Drugs·T D HolimonT H Self
Sep 8, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Milind P SovaniAnne E Tattersfield
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates
Jul 20, 2007·The Cochrane Database of Systematic Reviews·A K H TeeL B Irving
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Muireann Ni ChroininFrancine M Ducharme
May 14, 2010·The Cochrane Database of Systematic Reviews·Francine M DucharmeToby J Lasserson
Jan 27, 2006·The Cochrane Database of Systematic Reviews·P SeddonT J Lasserson
Apr 16, 2010·The Cochrane Database of Systematic Reviews·Francine M DucharmeToby J Lasserson