SALMO and S3M: A Saliva Model and a Single Saliva Salt Model for Equilibrium Studies

Bioinorganic Chemistry and Applications
Francesco CreaSilvio Sammartano

Abstract

A model of synthetic saliva (SALMO, SALiva MOdel) is proposed for its use as standard medium in in vitro equilibrium and speciation studies of real saliva. The concentrations come out from the literature analysis of the composition of both real saliva and synthetic saliva. The chief interactions of main inorganic components of saliva, as well as urea and amino acids, are taken into account on the basis of a complex formation model, which also considers the dependence of the stability constants of these species on ionic strength and temperature. These last features allow the modelling of the speciation of saliva in different physiological conditions deriving from processes like dilution, pH, and temperature changes. To simplify equilibrium calculations, a plain approach is also proposed, in order to take into account all the interactions among the major components of saliva, by considering the inorganic components of saliva as a single 1 : 1 salt (MX), whose concentration is c MX = (1/2)∑c i (c i = analytical concentration of all the ions) and z ion charge calculated as z=±(I/c MX)(1/2) = ±1.163. The use of the Single Saliva Salt Model (S3M) considerably reduces the complexity of the systems to be investigated. In fact, only fou...Continue Reading

References

Oct 31, 2008·Talanta·J Y GalM Adib-Yadzi
Oct 31, 2008·Talanta·Francesco CreaSilvio Sammartano
Oct 31, 2008·Talanta·Francesco CreaSilvio Sammartano
May 3, 2011·Current Microbiology·Marika BjörklundSofia D Forssten
Jul 17, 2012·AAPS PharmSciTech·Trevor RileySvetlana Lyapustina
Nov 6, 2012·International Journal of Pharmaceutics·David Elder, René Holm
Nov 6, 2013·Advanced Drug Delivery Reviews·Hannah K BatchelorSandra Klein
Jun 18, 2014·Current Medicinal Chemistry·Francesco CreaSilvio Sammartano

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Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia BertoPier Giuseppe Daniele

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Software Mentioned

ES4ECI
SALMO
SALiva MOdel

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