Salmonella enterica: a surprisingly well-adapted intracellular lifestyle.

Frontiers in Microbiology
Thomas DandekarMichael Hensel

Abstract

The infectious intracellular lifestyle of Salmonella enterica relies on the adaptation to nutritional conditions within the Salmonella-containing vacuole (SCV) in host cells. We summarize latest results on metabolic requirements for Salmonella during infection. This includes intracellular phenotypes of mutant strains based on metabolic modeling and experimental tests, isotopolog profiling using (13)C-compounds in intracellular Salmonella, and complementation of metabolic defects for attenuated mutant strains towards a comprehensive understanding of the metabolic requirements of the intracellular lifestyle of Salmonella. Helpful for this are also genomic comparisons. We outline further recent studies and which analyses of intracellular phenotypes and improved metabolic simulations were done and comment on technical required steps as well as progress involved in the iterative refinement of metabolic flux models, analyses of mutant phenotypes, and isotopolog analyses. Salmonella lifestyle is well-adapted to the SCV and its specific metabolic requirements. Salmonella metabolism adapts rapidly to SCV conditions, the metabolic generalist Salmonella is quite successful in host infection.

Citations

May 2, 2013·PLoS Pathogens·Benjamin SteebDirk Bumann
Sep 11, 2014·Database : the Journal of Biological Databases and Curation·Zeeshan AhmedThomas Dandekar
Aug 11, 2015·Frontiers in Microbiology·Gungor BudakNurcan Tuncbag
Apr 29, 2014·Cell·Etienne Maisonneuve, Kenn Gerdes
Oct 5, 2013·Free Radical Biology & Medicine·R Steven EsworthyFong-Fong Chu
Aug 1, 2014·Frontiers in Cellular and Infection Microbiology·Kai Papenfort, Jörg Vogel
Oct 18, 2014·Frontiers in Cellular and Infection Microbiology·Dirk Hofreuter
Feb 8, 2018·Environmental Microbiology Reports·Arthur ThompsonKarsten Tedin
Oct 20, 2017·Omics : a Journal of Integrative Biology·Aryashree ArunimaMrutyunjay Suar
Jul 4, 2017·Cellular Microbiology·Dirk Bumann, Joep Schothorst
Aug 30, 2017·Frontiers in Cellular and Infection Microbiology·Liljana PetrovskaRichard M Irvine
Apr 16, 2021·Advanced Drug Delivery Reviews·Robert Richter, Claus-Michael Lehr
Sep 30, 2021·Microbiology and Molecular Biology Reviews : MMBR·Erin F BoulangerBrian M M Ahmer

❮ Previous
Next ❯

Methods Mentioned

BETA
gene knockout

Software Mentioned

BiGG
KEGGbrowser
EMA
YANAsquare
COBRA Toolbox
YANAvergence

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.