Salmonella enterica serovar enteritidis burden in broiler breeder chicks genetically associated with vaccine antibody response

Avian Diseases
M G KaiserS J Lamont

Abstract

The relationship between antibody response to Salmonella enteritidis vaccine and internal organ burden of S. enteritidis is not fully understood. The genetic relationship, therefore, between postchallenge S. enteritidis burden and antibody response to S. enteritidis vaccine was determined in broiler breeder chicks. Sibling chicks from a broiler breeder male line were either inoculated with a pathogenic S. enteritidis or vaccinated with a commercial S. enteritidis vaccine. Spleen, liver, cecal wall, and cecal content samples from S. enteritidis-challenged chicks (n = 120) were cultured for enumeration of bacteria. Unchallenged chicks (n = 314) were vaccinated at 11 days of age, and serum samples were taken at 10 days postvaccination. Antibody response to vaccination and number of S. enteritidis in cecal content cultures were negatively correlated (-0.772), demonstrating that genetic potential for greater antibody response to S. enteritidis vaccine is associated with lesser S. enteritidis bacterial burden in cecal content of broiler breeder chicks. The findings suggest that genetic selection for vaccine antibody responsiveness can lower bacterial burden in the gut lumenal content and, thus, potentially reduce contamination of pou...Continue Reading

References

May 1, 1996·British Poultry Science·J ProtaisG Bennejean
Aug 26, 1998·Poultry Science·S J Lamont
Oct 8, 1999·Emerging Infectious Diseases·P S MeadR V Tauxe

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Citations

May 23, 2006·Infection and Immunity·Jason R HasensteinSusan J Lamont
May 1, 2010·Genetics, Selection, Evolution : GSE·Fanny CalengeCatherine Beaumont
May 14, 2003·Immunogenetics·Huaijun Zhou, Susan J Lamont

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

JMP

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