Salmonella enterica serovar Enteritidis colonization of the chicken caecum requires the HilA regulatory protein

Veterinary Microbiology
Lotte BohezF Van Immerseel

Abstract

Invasion of Salmonella into intestinal epithelial cells is believed to be essential for the pathogenesis of Salmonella infections. Invasion is mediated by genes located on the Salmonella pathogenicity Island I (SPI-1), which are needed for assembling a type three secretion system, that mediates injection of bacterial proteins into the cytosol of epithelial cells, resulting in cytoskeletal rearrangements and as a consequence invasion. HilA is the key regulator of the Salmonella Pathogenicity Island I. To assess the role of hilA in colonization of gut and internal organs in poultry, animals were infected with 10(8) CFU of a delta hilA mutant of S. Enteritidis and its parent strain at day of hatch. Very low numbers of delta hilA mutant strain were able to colonize the internal organs shortly after infection, but they were not eliminated from internal organs at 4 weeks post-infection. At that time, the colonization level of the wild type bacteria in internal organs was decreased to the same low level compared with delta hilA mutant strain bacteria. Shedding of the delta hilA mutant strain and colonization of the caeca was seriously decreased relative to the parent strain starting from Day 5 post-infection. At 4 weeks post-infection...Continue Reading

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Citations

May 17, 2011·Applied and Environmental Microbiology·Steven L FoleySteven C Ricke
Dec 17, 2015·Current Microbiology·Lilian C CarneiroLuiz Artur M Bataus
Nov 21, 2012·Journal of Food Science·Francisco González-GilIrene Hanning
Jun 20, 2018·Environmental Microbiology·Pierrette MenanteauPhilippe Velge
Mar 20, 2014·Infection and Immunity·Shaikh M AtifAndreas J Bäumler
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·Steven L FoleyJessica Danzeisen
Nov 27, 2019·Pathogens·Julia A Hotinger, Aaron E May

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