Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages

FEBS Letters
Miyuki KawanoKiyoshi Kawasaki

Abstract

Modification of lipid A is essential for bacterial adaptation to its host. Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-O-deacylation; however, the involvement of deacylation in its adaptation remains unclear. LpxR-dependent 3'-O-deacylation was observed in the stationary phase. When macrophages were infected with stationary phase bacteria, the intracellular growth of the lpxR-null strain was lower than that of the wild-type strain. Furthermore, the expression level of inducible nitric oxide synthase was higher in the cells infected with the lpxR-null strain than in the cells infected with the wild-type strain. These results indicate that lipid A 3'-O-deacylation is beneficial for intracellular growth.

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Citations

Mar 24, 2015·Expert Review of Vaccines·Afshin Zariri, Peter van der Ley
Oct 23, 2012·Biochemical and Biophysical Research Communications·Kiyoshi KawasakiShoko Amamoto
Jun 12, 2010·Microbes and Infection·Amit LahiriDipshikha Chakravortty
Sep 12, 2013·Current Opinion in Microbiology·Disa L HammarlöfJay C D Hinton
Jul 26, 2017·Critical Reviews in Microbiology·Charlotte VolgersFrank R M Stassen
Jan 1, 2014·Journal of Bacteriology·Brianna L PetroneJoseph T Wade
Apr 8, 2020·Infection and Immunity·Nicole P GiordanoZachary D Dalebroux
Jan 19, 2019·International Journal of Molecular Sciences·Gracjana Klein, Satish Raina

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