PMID: 8580903Sep 1, 1995Paper

Salmonella typhi does not inhibit phagosome-lysosome fusion in human monocyte-derived macrophages

FEMS Immunology and Medical Microbiology
Y Ishibashi, T Arai

Abstract

We examined phagosome-lysosome fusion in Salmonella typhi-infected human monocyte-derived macrophages and its relevance to the intracellular survival of this bacterium in vitro. S. typhi was found to survive and multiply in human monocyte-derived macrophages, whereas S. typhimurium was killed easily, indicating that the survival of Salmonella serovars is host-specific. Neither S. typhi nor S. typhimurium inhibited phagosome-lysosome fusion in human monocyte-derived macrophages. No difference between the phagosome-lysosome fusibilities of freshly prepared human monocytes and monocyte-derived macrophages was observed. These results suggest that S. typhi may survive by adapting to the conditions within fused phagolysosomes of human monocyte-derived macrophages.

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Citations

Jan 5, 2002·Developmental and Comparative Immunology·F PasmansF Haesebrouck
Dec 12, 2012·Virulence·A Leoni Swart, Michael Hensel
Sep 24, 1999·Electrophoresis·Y A Kwaik, O S Harb
Feb 26, 2011·Immunological Reviews·Jonathan JantschMichael Hensel
Aug 8, 2009·Microbial Pathogenesis·Tong XuKathleen L McGuire

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