PMID: 6112529May 30, 1981Paper

Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole

Lancet
N DattaC Datta

Abstract

Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.

References

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Citations

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