PMID: 8595853Jan 15, 1996Paper

Salmonella typhimurium acrB-like gene: identification and role in resistance to biliary salts and detergents and in murine infection

FEMS Microbiology Letters
F J LacroixP Pardon

Abstract

Salmonella serotype typhimurium transpositional mutants altered in resistance to biliary salts and detergents were isolated previously. We have characterized further the LX1054 mutant strain, the most sensitive of them. The chromosomal DNA segment flanking transposon insertion was cloned and sequenced. The highest level of identity was found for the acrB (formerly acrE) gene of Escherichia coli, a gene encoding a drug efflux pump of the Acr family. LX1054 exhibited a reduced capacity to colonize the intestinal tract. After passages in mice, the mutant strain lost the sensitive phenotype. In vitro, a resumption of growth appeared after 17 h of culture in medium with cholate or other tested biological or chemical detergents. Then, the acquired resistant phenotype seemed stable. The data suggested a role of S. typhimurium acrB-like gene in resistance to biliary salts and detergents and in mice intestinal colonization. However, the local and transient sensitivity observed in vivo, and the in vitro adaptations suggest that several detergent-resistance mechanisms operate in S. typhimurium.

References

Apr 1, 1992·Antimicrobial Agents and Chemotherapy·S B Levy
Nov 1, 1991·Molecular & General Genetics : MGG·J R KleinR Plapp
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 1, 1986·Annales De L'Institut Pasteur. Microbiology·P PardonI Miras
Dec 1, 1994·Trends in Microbiology·D MaH Nikaido
Mar 1, 1994·Trends in Biochemical Sciences·K Lewis
Jan 1, 1993·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J W DingS Bengmark

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Citations

Jun 9, 2005·Advanced Drug Delivery Reviews·Ayush Kumar, Herbert P Schweizer
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Jan 1, 1997·International Journal of Antimicrobial Agents·M Ouellette, C Kündig
Aug 30, 2000·Microbes and Infection·J S Gunn
Sep 30, 2008·The Journal of Antimicrobial Chemotherapy·Nicolás A VillagraGuido C Mora
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·K Poole
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Jun LinQijing Zhang
Mar 24, 2009·Applied and Environmental Microbiology·Miguel GueimondeAbelardo Margolles
Oct 5, 2012·Clinical Microbiology Reviews·Lucía Fernández, Robert E W Hancock
Apr 15, 2006·Clinical Microbiology Reviews·Laura J V Piddock
Jul 5, 2011·Journal of Bacteriology·Julianne V KusDebora Barnett Foster
Sep 9, 2008·Journal of Bacteriology·Francisca A Cerda-MairaRonald K Taylor
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Apr 14, 2006·Cellular Microbiology·Anthony M BuckleyLaura J V Piddock
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