Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice

European Journal of Immunology
Paola ZacconeAnne Cooke

Abstract

Infectious disease has been proposed as an environmental modifier of autoimmunity in both human populations and the NOD mouse. We found that infection of NOD mice with attenuated, but not killed, Salmonella typhimurium can reduce the incidence of type 1 diabetes (T1D), even if infection occurs after the development of a peri-islet pancreatic infiltrate. Functional diabetogenic effector T cells are still present, as demonstrated by the initiation of diabetes in NOD-scid recipients of transferred splenocytes. High levels of IFN-gamma are secreted by splenocytes of infected mice, but there is no evidence of involvement of IL-10 in the protective effect of the infection. Finally, prolonged changes in cell subsets are observed in infected mice involving invariant Valpha14Jalpha281 NuKappaTau and dendritic cells. These data reinforce the idea that prevention of T1D in the NOD mouse cannot be reduced to the simple Th1/Th2 paradigm and that different infections may involve different protective mechanisms.

References

Apr 1, 1991·Journal of Autoimmunity·M Debray-SachsJ F Bach
Oct 1, 1996·The Journal of Experimental Medicine·T De SmedtM Moser
Jan 10, 1998·Clinical and Diagnostic Laboratory Immunology·D O Sobel, J Newsome
Sep 7, 2000·The Journal of Experimental Medicine·J L MatsudaM Kronenberg
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D V SerrezeA Rabinovitch
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y N NaumovS B Wilson
Dec 19, 2001·Infection and Immunity·Hans-Willi MittrückerStefan H E Kaufmann
Dec 26, 2001·International Immunology·Francesca FallarinoPaolo Puccetti
Jul 11, 2002·Current Molecular Medicine·Pietro Mastroeni
Aug 8, 2002·Diabetes Technology & Therapeutics·Anjli Kukreja, Noel K Maclaren
Nov 7, 2002·Journal of Autoimmunity·Anjli KukrejaNoel Maclaren
Nov 7, 2002·Journal of Autoimmunity·Douglas O SobelBehrouz Ahvazi
Jul 2, 2003·The Journal of Experimental Medicine·Ursula GrohmannPaolo Puccetti
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luis M EstebanAlan G Baxter

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Citations

Jun 21, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Samuel W Hall, Anne Cooke
May 14, 2008·The Journal of Experimental Medicine·Martin HoldenerUrs Christen
Mar 27, 2012·International Immunology·David BendingAnne Cooke
May 5, 2009·Current Opinion in Rheumatology·Wendy Gaisford, Anne Cooke
Jun 10, 2011·Clinical and Vaccine Immunology : CVI·Wendy GaisfordAnne Cooke
Oct 18, 2006·Infection and Immunity·Karin A SaundersCatherine E Lawrence
Jan 1, 2012·The Review of Diabetic Studies : RDS·Paola Zaccone, Samuel W Hall
Jan 1, 2013·Pathogens·Gabriele SorciBruno Faivre
Sep 26, 2015·Journal of Autoimmunity·James A PearsonLi Wen
Feb 8, 2011·Seminars in Immunology·Paola Zaccone, Anne Cooke
Jun 15, 2007·Biochimie·Jacques-Eric Gottenberg, Gilles Chiocchia
Jan 6, 2009·Annals of the New York Academy of Sciences·F Susan Wong, Li Wen
Sep 13, 2006·Parasite Immunology·P ZacconeA Cooke
Jul 28, 2011·European Journal of Immunology·Stephen A NewlandAnne Cooke
Apr 28, 2009·Autoimmunity Reviews·Elad Goldberg, Ilan Krause
Jun 27, 2015·Journal of Immunology Research·Ljiljana Sofronic-MilosavljevicAlisa Gruden-Movsesijan
Nov 26, 2008·Blood Cells, Molecules & Diseases·Anne Cooke
Jan 8, 2013·International Journal for Parasitology·Paola Zaccone, Anne Cooke
May 27, 2017·Experimental & Molecular Medicine·Naeun Lee, Wan-Uk Kim
Aug 30, 2018·Human Vaccines & Immunotherapeutics·James A PearsonLi Wen
Feb 23, 2010·Nature Reviews. Endocrinology·Nikolai Petrovsky
Jun 26, 2010·Nature Reviews. Immunology·Agnès LehuenAnne Cooke
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim RaineAnne Cooke
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James DoonanWilliam Harnett
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urs Christen, Matthias G von Herrath

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