Salmonella vaccines: lessons from the mouse model or bad teaching?

Current Opinion in Microbiology
Richard A StrugnellAndreas Kupz

Abstract

Salmonella enterica subsp. enterica includes several very important human serovars including Typhi, Paratyphi, Typhimurium and Enteritidis. These bacteria cause a significant global burden of disease, typically classified into enteric fever, gastroenteritis and, more recently, invasive non-typhoidal salmonellosis (iNTS). Vaccines have been developed for one of these serovars, S. Typhi and the recent increase in iNTS cases has resulted in a push to develop new vaccines that will inhibit disease by S. Typhimurium and S. Enteritidis, the most common iNTS S. enterica serovars. The development of new human vaccines has been informed by studies in the murine model of typhoid fever based on S. Typhimurium infections of very 'sensitive' (Nramp-1(S)) mice, which has some obvious deficiencies, not the least that antibodies protect humans against S. Typhi infection but are only weakly protective in 'sensitive' mice infected with S. Typhimurium. S. Typhimurium also lacks Vi, the target of protective antibodies in typhoid fever. Notwithstanding these deficiencies, the murine model has identified a very complex series of innate and adaptive immune responses to infection that might be exploited to develop new vaccines. Equally, advances in un...Continue Reading

References

Jan 5, 2002·Microbes and Infection·Renato L SantosAndreas J Bäumler
Oct 23, 2004·The Journal of Infectious Diseases·Calman A MacLennanDinakantha S Kumararatne
Jul 14, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen Baker, Gordon Dougan
Sep 1, 1949·Postgraduate Medical Journal·J C S PATERSON
Apr 29, 2008·Bulletin of the World Health Organization·R Leon OchiaiDomi Typhoid Study Group
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Melita A GordonMalcolm E Molyneux
Jul 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan C MorpethJohn A Crump
Oct 13, 2009·Trends in Microbiology·Renato L SantosAndreas J Bäumler
Dec 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Crump, Eric D Mintz
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Esther N GondweCalman A MacLennan
Feb 18, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shannon E MajowiczInternational Collaboration on Enteric Disease 'Burden of Illness' Studies
Apr 24, 2010·Science·Calman A MacLennanMalcolm E Molyneux
Jun 1, 2010·The Lancet Infectious Diseases·Elizabeth A ReddyJohn A Crump
Jun 15, 2010·Current Opinion in HIV and AIDS·Satya DandekarAndreas J Bäumler
Oct 19, 2010·Cell Host & Microbe·Jeongmin SongJorge E Galán
Feb 24, 2011·Infection and Immunity·Renée M TsolisAndreas J Bäumler
Jul 12, 2011·Cellular Microbiology·Ivan GodinezAndreas J Bäumler
Aug 23, 2011·Applied and Environmental Microbiology·Pierre WattiauSophie Bertrand
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Seung-Joo LeeStephen J McSorley
Oct 30, 2012·Cell·Ferric C Fang, Andreas J Bäumler
Oct 30, 2012·Cell·Ramkumar MathurSankar Ghosh
Apr 9, 2013·Human Vaccines & Immunotherapeutics·Rachel B SlaytonEric D Mintz
Jul 11, 2013·The Pediatric Infectious Disease Journal·Nicole StoesserChristopher M Parry
Aug 24, 2013·Genome Announcements·Deqi XuDennis J Kopecko
Sep 24, 2013·Expert Review of Vaccines·Kenneth L Roland, Karen E Brenneman

Citations

Apr 22, 2015·Human Vaccines & Immunotherapeutics·Malabi M Venkatesan, Lillian L Van de Verg
Nov 13, 2015·PLoS Pathogens·Shabarinath SrikumarJay C D Hinton
Jul 15, 2016·Clinical and Vaccine Immunology : CVI·Ellen E HigginsonSharon M Tennant
Dec 10, 2016·The Journal of Biological Chemistry·Vikash SinghKarsten Tedin
Apr 27, 2018·Microbiology and Molecular Biology Reviews : MMBR·Hyun Jae LeeAubrey J Cunnington
Apr 24, 2020·International Journal of Molecular Medicine·Yong ZhiSangyong Lim
Oct 28, 2017·Frontiers in Microbiology·Christopher J Anderson, Melissa M Kendall

Related Concepts

Salmonella Infections
Salmonella Vaccines
Antigens
Gastroenteritis
Laboratory mice
Typhoid Fever
Vaccines
Vitamin D Deficiency
Salmonella enterica
Salmonella Vaccines

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