Salmonella VNP20009-mediated RNA interference of ABCB5 moderated chemoresistance of melanoma stem cell and suppressed tumor growth more potently

Oncotarget
Xiaoxin ZhangZi-Chun Hua

Abstract

Drug resistance remains an obstacle hindering the success of chemotherapy. Cancer stem cells (CSCs) have been recently found to confer resistance to chemotherapy. Therefore functional markers of CSCs should be discovered and specific therapies targeting these cells should be developed. In our investigation, a small population of B16F10 cells which was positive for ATP-binding cassette sub-family B member 5 (ABCB5) was isolated. This population displayed characteristics similar to those of CSCs and ABCB5 was identified to confer tumor growth and drug resistance in B16F10 cell line. Although targeting ABCB5 by small short interfering RNA delivered by VNP20009 failed to inhibit tumor growth, the combined treatment of VNP-shABCB5 and chemotherapy can act synergistically to delay tumor growth and enhance survival time in a primary B16F10 mice model. Results suggest that the combined treatment of VNP-shABCB5 and chemotherapy can improve the efficacy of chemotherapeutic drugs. Therefore, this combination therapy is of potential significance for melanoma treatment.

References

Mar 8, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J BläckbergK Kidd-Ljunggren
Jun 6, 2003·Oncogene·María S Soengas, Scott W Lowe
Sep 10, 2003·The Journal of Biological Chemistry·Natasha Y FrankMarkus H Frank
May 16, 2006·Nature Biotechnology·Shuanglin XiangChiang J Li
Jul 11, 2006·The New England Journal of Medicine·Arlo J Miller, Martin C Mihm
Feb 27, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elena MonzaniCaterina A M La Porta
Jan 19, 2008·Nature·Tobias SchattonMarkus H Frank
Feb 19, 2008·Biochemical and Biophysical Research Communications·Gilmor I KeshetGideon Rechavi
Mar 11, 2008·Cancer Cell·Susan E Zabierowski, Meenhard Herlyn
Jul 20, 2010·The Journal of Surgical Research·Bhuvnesh K SharmaE George Elias
Oct 28, 2010·Biochemical and Biophysical Research Communications·Jie MaMarkus H Frank
Jan 29, 2011·The Journal of Investigative Dermatology·Verena KupasKarin Loser
Oct 21, 2011·Nature·Corine BertolottoBrigitte Bressac-de Paillerets
Jan 13, 2012·Nature Reviews. Cancer·Long V NguyenConnie J Eaves
Feb 4, 2012·The Lancet Oncology·Louis VermeulenJan Paul Medema
Feb 4, 2012·Cancer Metastasis Reviews·Adrian Biddle, Ian C Mackenzie
Jun 8, 2012·PloS One·Marine ChartrainJean Philippe Annereau
Oct 10, 2012·Experimental Biology and Medicine·Wen-Wei ChangChe-Hsin Lee
Feb 2, 2013·Clinical and Translational Medicine·Lissa Nurrul Abdullah, Edward Kai-Hua Chow
Apr 4, 2013·Nature Cell Biology·Jan Paul Medema
Sep 26, 2013·Nature Reviews. Cancer·Benjamin Beck, Cédric Blanpain
Oct 8, 2013·Oncogene·S J VidalJ Domingo-Domenech
Mar 13, 2014·Cell Stem Cell·Antonija Kreso, John E Dick
May 27, 2015·Melanoma Research·Christina L RolandAnthony Lucci

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Citations

Jul 15, 2016·Scientific Reports·Xiaoxin ZhangZichun Hua
Mar 25, 2017·International Journal of Cancer. Journal International Du Cancer·Jian-Qin TangGuan Jiang
Dec 13, 2019·Experimental & Molecular Medicine·Mai Thi-Quynh DuongJung-Joon Min
Apr 4, 2018·Current Medicinal Chemistry·Sanaz NaghizadehBehzad Baradaran
Jul 3, 2019·Seminars in Cancer Biology·Monica MarzagalliPatrizia Limonta
Mar 20, 2021·Frontiers in Oncology·Fereshteh BadieHamed Mirzaei
May 13, 2021·Seminars in Cancer Biology·Deepti DiwanVijai Kumar Gupta

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Methods Mentioned

BETA
transfection
PCR

Software Mentioned

StepOne
ELDA
GraphPad Prism
CELLQUEST

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