"Salt and Pepper Endothelium" Recurring After Descemet Membrane Endothelial Keratoplasty

Cornea
Maria SatuéGerrit R J Melles

Abstract

To describe the presence of "salt and pepper endothelium", that is, typical cellular inclusion bodies in a patient with Fuchs endothelial corneal dystrophy (FECD), that recurred in the donor corneal endothelial cells after Descemet membrane endothelial keratoplasty (DMEK). A 76-year-old man underwent DMEK for FECD in his left eye. Routine specular microscopy imaging, best-corrected visual acuity measurements, and pachymetry measurements were performed before and after surgery. Besides large guttae indicating FECD, preoperative specular microscopy images showed variable-sized dark cellular inclusion bodies in the endothelial cells. One month after DMEK, donor endothelial cells appeared normal; however, at 3 months, the typical inclusion bodies reappeared and progressed slowly within a 4-year follow-up period. Both best-corrected visual acuity and pachymetry were stable throughout the study period. "Salt and pepper endothelium" recurred after the host tissue was exchanged by donor Descemet membrane, that is, a DMEK graft. These changes may indicate that either the donor corneal endothelial cell morphology is modified by adjacent tissue structures or that it is completely replaced by recipient endothelium within the first months a...Continue Reading

References

Jan 12, 2011·Archives of Ophthalmology·Isabel DapenaGerrit R J Melles
Nov 1, 2011·Ophthalmology·Toine HillenaarLies Remeijer
May 29, 2012·American Journal of Ophthalmology·Martin DirisamerGerrit R J Melles
Oct 31, 2012·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Korine van DijkGerrit R J Melles
May 30, 2013·Ophthalmology·Ana Boto-de-Los-BueisPaolo Rama

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