Salt, but not protein intake, is associated with accelerated disease progression in autosomal dominant polycystic kidney disease.

Kidney International
Bart J KramersEsther Meijer

Abstract

In autosomal dominant polycystic kidney disease (ADPKD), there are only scarce data on the effect of salt and protein intake on disease progression. Here we studied association of these dietary factors with the rate of disease progression in ADPKD and what the mediating factors are by analyzing an observational cohort of 589 patients with ADPKD. Salt and protein intake were estimated from 24-hour urine samples and the plasma copeptin concentration measured as a surrogate for vasopressin. The association of dietary intake with annual change in the estimated glomerular filtration rate (eGFR) and height adjusted total kidney volume (htTKV) growth was analyzed with mixed models. In case of significant associations, mediation analyses were performed to elucidate potential mechanisms. These patients (59% female) had a mean baseline age of 47, eGFR 64 mL/min/1.73m2 and the median htTKV was 880 mL. The mean estimated salt intake was 9.1 g/day and protein intake 84 g/day. During a median follow-up of 4.0 years, eGFR was assessed a median of six times and 24-hour urine was collected a median of five times. Salt intake was significantly associated with annual change in eGFR of -0.11 (95% confidence interval 0.20 - -0.02] mL/min/1.73m2) pe...Continue Reading

Citations

Jan 13, 2021·Néphrologie & thérapeutique·Mouad HamzaouiDominique Guerrot
Mar 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Charlotte GimpelDjalila Mekahli
Jul 16, 2021·Current Opinion in Nephrology and Hypertension·Esther Meijer, Ron T Gansevoort
Aug 28, 2021·Nutrients·Massimo CirilloMartino Laurenzi
Nov 11, 2021·Advances in Nutrition·Lauren PickelHoon-Ki Sung

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