PMID: 1592463Jun 1, 1992Paper

Salt-dependent hypertension in the sinoaortic-denervated rat

Hypertension
J W Osborn, B J Provo

Abstract

To determine the extent to which baroreceptor function is a determinant of salt-dependent hypertension, we studied the cardiovascular and renal responses to increasing dietary sodium chloride in sinoaortic-denervated (n = 9) and sham-denervated (n = 9) Sprague-Dawley rats. Rats were instrumented with an arterial catheter for measurement of arterial pressure and were individually housed for daily measurements of water intake, sodium intake, urinary output, and urinary sodium excretion. Arterial pressure was monitored daily over a 30-minute period by computer. After 3 days of control measurements (0.4% sodium chloride diet), dietary sodium chloride was increased to 8.0% for 21 days, followed by a 3-day recovery period (0.4% sodium chloride). Ingestion of an 8.0% sodium chloride diet resulted in a 20- to 25-fold increase in sodium intake and a fivefold increase in water intake in both groups. In sinoaortic-denervated rats, arterial pressure increased approximately 10 mm Hg on days 5-10, 20 mm Hg on days 11-18, and 30 mm Hg on days 19-21 of 8.0% sodium chloride. Arterial pressure returned to control levels within the first 24 hours of the recovery period. Elevated sodium intake had no significant effect on arterial pressure in the ...Continue Reading

References

Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·E Miyajima, R D Buñag
Oct 1, 1985·Journal of Hypertension·P R HoweJ B Minson
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·M T Velasquez, N Alexander

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Citations

May 2, 2003·Current Hypertension Reports·J Michael Wyss, Scott H Carlson
Aug 23, 2011·Journal of Biosciences·Waleska C Dornas, Marcelo E Silva
Jul 22, 1998·Journal of the Autonomic Nervous System·Q H ChenH Kosaka
Jan 1, 1997·Brain Research Bulletin·M J RochaM Morris
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·J W Osborn
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·John W OsbornPilar Guzman
Oct 7, 2015·Clinical and Experimental Pharmacology & Physiology·Elaine F SilvaGustavo R Pedrino
Oct 6, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Rodríguez-MartínezL Llamazares-Azuara
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·J W OsbornS H Carlson
Oct 5, 2002·Hypertension·Gerald F DiBona, Linda L Sawin
Feb 4, 1999·Hypertension·J M VanNessJ R Haywood
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John W OsbornPilar Guzman
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S D StockerA F Sved
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Michael D Hendel, John P Collister
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Nov 26, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Terry N Thrasher
Apr 30, 2017·Current Hypertension Reports·Masha Prager-KhoutorskyCharles W Bourque
Mar 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Frédéric JacobJohn W Osborn
Nov 14, 1998·The American Journal of Physiology·J W Osborn, B J Hornfeldt

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