Salt induced lamellar to bicontinuous cubic phase transitions in cationic nanoparticles

The Journal of Physical Chemistry. B
Benjamin W MuirPatrick G Hartley

Abstract

The development of improved methods to allow the low energy production of cubic phase forming nanoparticles (cubosomes) is highly desired. The lamellar to hexagonal and cubic phase change of these lipid nanoparticles has previously been induced via the lowering of pH and the addition of calcium ions to anionic lipid nanoparticles. We have developed a method to produce low polydispersity cubosomes without the requirement of high energy input such as shear, sonication or homogenization under physiological conditions. We have found that the simple addition of phosphate buffered saline solution to aqueous dispersions of cationic liposome vesicles made with phytantriol results in the spontaneous formation of cubosomes after vortex mixing. This finding demonstrates the potential of utilizing this technique to incorporate shear and temperature sensitive compounds into cubosomes under extremely mild conditions for biomedical and nanotechnological applications.

References

Oct 31, 1998·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·L S NielsenJ Hansen
Apr 11, 2003·Journal of Colloid and Interface Science·Matthew L LynchPatrick T Spicer
Jul 5, 2003·International Journal of Pharmaceutics·Ben J Boyd
Mar 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Justas BarauskasFredrik Tiberg
Sep 16, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·John M SeddonRichard H Templer
Sep 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Rivka EfratDganit Danino
Apr 15, 2010·Journal of Fluorescence·Magda PrzybyloMarek Langner
Jun 29, 2010·International Journal of Pharmaceutics·Xavier MuletCalum J Drummond
Jul 31, 2010·The Journal of Physical Chemistry. B·Rivka EfratNissim Garti

❮ Previous
Next ❯

Citations

Sep 25, 2012·ACS Combinatorial Science·Oliver E HuttG Paul Savage
Apr 2, 2014·Advances in Colloid and Interface Science·Isabelle MartielRaffaele Mezzenga
Feb 5, 2014·Expert Opinion on Drug Delivery·Alexandre LancelotJosé Luis Serrano
Mar 10, 2015·Expert Opinion on Drug Delivery·Terence E HartnettKatharina Ladewig
Jan 15, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Jan 19, 2016·Drug Discovery Today·Zahra Karami, Mehrdad Hamidi
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexandru Zabara, Raffaele Mezzenga
May 6, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Qingtao LiuBen J Boyd
May 20, 2016·Drug Delivery and Translational Research·Joanne D DuBen J Boyd
Sep 14, 2016·Journal of Colloid and Interface Science·Wye-Khay FongBen J Boyd
Feb 25, 2017·Chembiochem : a European Journal of Chemical Biology·Behnoosh Tajik-AhmadabadAnastasios Polyzos
Aug 21, 2018·Physical Chemistry Chemical Physics : PCCP·S SalentinigH Amenitsch
Jun 22, 2018·Angewandte Chemie·Hanna M G BarrigaMolly M Stevens
Feb 4, 2021·Physical Chemistry Chemical Physics : PCCP·Colin P PilkingtonYuval Elani
Apr 13, 2021·Colloids and Surfaces. B, Biointerfaces·Polina NaidjonokaTommy Nylander
Jun 21, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Oct 12, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Qingtao LiuBen J Boyd
Sep 17, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Chantelle D DrieverCalum J Drummond
Oct 3, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Toshihiko OkaMasahito Yamazaki
Oct 13, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Paola AstolfiMichela Pisani
Jun 11, 2014·The Journal of Physical Chemistry. B·Terence E HartnettKeith M McLean
Dec 9, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Isabelle MartielRaffaele Mezzenga
Jul 31, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Pabitra MaitySanat Karmakar
Dec 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Zhen LiZhongni Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.