Salt, inflammation, IL-17 and hypertension

British Journal of Pharmacology
Ulrich WenzelHeimo Ehmke

Abstract

Traditionally, arterial hypertension and subsequent end-organ damage have been attributed to haemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign microorganisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune system overreacts to internal injury, such as prehypertension. Over the past few years, important findings have revolutionized hypertension research. Firstly, in 2007, a seminal paper showed that adaptive immunity is involved in the pathogenesis of hypertension. Secondly, salt storage in the skin and its consequences for cardiovascular physiology were discovered. Thirdly, after the discovery that salt promotes the differentiation of CD4+ T cells into TH 17 cells, it was demonstrated that salt directly changes several cells of the innate and adaptive immune system and aggravates autoimmune disease but may improve antimicrobial defence. Herein, we will review pathways of activation of immune cells by salt in hypertension as the framework for understanding the multiple roles of salt and immunity in ...Continue Reading

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Citations

Jan 23, 2020·Journal of Clinical Medicine·Carolina LavozMarta Ruiz-Ortega
Jun 26, 2020·British Journal of Pharmacology·Ulrich O WenzelMarlies Bode
May 28, 2019·British Journal of Pharmacology·Antony VinhChristopher G Sobey
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Jan 5, 2021·Cell and Tissue Research·Ulrich O WenzelMarlies Bode
Apr 2, 2021·Circulation Research·David G HarrisonChristopher S Wilcox
Sep 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anja BernhardtPeter R Mertens

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