Salt intake and reductions in arterial pressure and proteinuria. Is there a direct link?

American Journal of Hypertension
G L Bakris, M R Weir

Abstract

The preponderance of the medical literature supports the concept that modest or moderate dietary salt restriction enhances the blood pressure lowering responses to most antihypertensive medications and may permit either dose reduction or, in a few cases, complete drug withdrawal. Moreover, reduction in salt intake has a permissive action on the antiproteinuric responses of angiotensin converting enzyme inhibitors and nondihydropyridine calcium channel blockers. It does not, however, affect proteinuria in those receiving dihydropyridine calcium channel blockers. The importance of selecting out those individuals who can most benefit from dietary salt modification (the "salt sensitive" groups of hypertensive patients) is important. Prospective randomized clinical studies are needed to assess the correlation between dietary salt intake and renal endpoints, such as time dialysis. This will be particularly important in different demographic groups that may have a greater predisposition to salt sensitivity, such as elderly or obese hypertensives, hypertensives of black or Hispanic descent, and those with non-insulin-dependent diabetes mellitus.

Citations

Mar 21, 2002·Diabetes, Obesity & Metabolism·R Estacio
Nov 13, 2004·The Journal of Clinical Hypertension·George L Bakris
Apr 9, 2009·Nature Reviews. Cardiology·Varun AgrawalPeter A McCullough
Oct 22, 2014·Nature Reviews. Nephrology·Nishank Jain, Robert F Reilly
May 30, 1998·Journal of Cardiovascular Pharmacology·K Makrilakis, G Bakris
May 11, 2004·Current Diabetes Reports·Nitin KhoslaGeorge L Bakris
Sep 3, 2004·Current Hypertension Reports·George L Bakris
Jan 16, 2009·Journal of the American Society of Nephrology : JASN·René R WenzelUNKNOWN SPP301 (Avosentan) Endothelin Antagonist Evaluation in Diabetic Nephropathy Study Investigators
Nov 17, 2020·Expert Review of Cardiovascular Therapy·Addisu Dabi Wake
Feb 8, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Matthew R Weir, Jeffrey C Fink
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Oct 17, 2017·Advances in Chronic Kidney Disease·Vivek Soi, Jerry Yee

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