Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies.

BMJ : British Medical Journal
Pasquale StrazzulloF P Cappuccio

Abstract

To assess the relation between the level of habitual salt intake and stroke or total cardiovascular disease outcome. Systematic review and meta-analysis of prospective studies published 1966-2008. Medline (1966-2008), Embase (from 1988), AMED (from 1985), CINAHL (from 1982), Psychinfo (from 1985), and the Cochrane Library. Review methods For each study, relative risks and 95% confidence intervals were extracted and pooled with a random effect model, weighting for the inverse of the variance. Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed. Criteria for inclusion were prospective adult population study, assessment of salt intake as baseline exposure, assessment of either stroke or total cardiovascular disease as outcome, follow-up of at least three years, indication of number of participants exposed and number of events across different salt intake categories. There were 19 independent cohort samples from 13 studies, with 177 025 participants (follow-up 3.5-19 years) and over 11 000 vascular events. Higher salt intake was associated with greater risk of stroke (pooled relative risk 1.23, 95% confidence interval 1.06 to 1.43; P=0.007) and cardiovascular disease (1.14, 0.99 to 1.32; P=0.07), ...Continue Reading

Associated Clinical Trials

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Methods Mentioned

BETA
urine collection
urine collection the

Software Mentioned

Embase
MIX
AMED
Stata
Psychinfo

Related Concepts

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