Salt loading enhances rat renal TxA2/PGH2 receptor expression and TGF response to U-46,619

The American Journal of Physiology
W J WelchC S Wilcox

Abstract

The tubuloglomerular feedback (TGF) response is potentiated by thromboxane A2 (TxA2) and/or prostaglandin endoperoxide (PGH2) acting on specific receptors. Infusion of the TxA2/PGH2 mimetic, U-46,619, into conscious rats leads to hypertension that is potentiated by a high-salt intake. Therefore, we tested the hypothesis that a high-salt intake enhances the expression of transcripts for TxA2/PGH2 receptors in the kidney and glomeruli and enhances the response of TGF to TxA2/PGH2 receptor stimulation. Groups of rats were accommodated to a low-salt (LS), normal salt (NS), or high-salt (HS) diet for 8-10 days. TxA2/PGH2 receptor mRNA was detected by reverse transcription-polymerase chain reaction in kidney cortex, isolated glomeruli, and abdominal aorta. TxA2/PGH2 mRNA abundance was significantly (P < 0.001) increased during intake of high-salt compared with low-salt diets in the kidney cortex (1.34 +/- 0.10 vs. 0.84 +/- 0.04 arbitrary units) and isolated outer cortical glomeruli (0.68 +/- 0.04 vs. 0.32 +/- 0.03 arbitrary units), but there was no effect of salt on TxA2/PGH2 receptor mRNA expression in the aorta. Maximal TGF responses were assessed from the increase in proximal stop flow pressure (an index of glomerular capillary pr...Continue Reading

References

Jun 1, 1992·The Journal of Clinical Investigation·W J Welch, C S Wilcox
Feb 1, 1992·Hypertension·T F LüscherZ H Yang
Dec 1, 1991·Kidney International·C S WilcoxH Snellen
Jan 16, 1989·Biochemical and Biophysical Research Communications·C P SungB A Berkowitz
Jun 1, 1988·The Journal of Clinical Investigation·W J Welch, C S Wilcox
May 1, 1996·Kidney International·B A BresnahanE A Lianos

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Citations

Jan 9, 2003·American Journal of Physiology. Renal Physiology·Christopher S Wilcox, William J Welch
Feb 13, 2003·American Journal of Physiology. Renal Physiology·Visith ThongboonkerdJohn M Arthur
Feb 22, 2001·Annual Review of Physiology·M D Breyer, R M Breyer
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Magali Araujo, William J Welch
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Pascale GluaisMichel Félétou
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James D KrierLilach O Lerman
Dec 23, 2004·American Journal of Physiology. Renal Physiology·William J Welch

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