Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4

Hypertension
Yanqiang YangVictor J Dzau

Abstract

Despite the importance of juxtaglomerular cell recruitment in the pathophysiology of cardiovascular diseases, the mechanisms that underlie renin production under conditions of chronic stimulation remain elusive. We have previously shown that CD44+ mesenchymal-like cells (CD44+ cells) exist in the adult kidney. Under chronic sodium deprivation, these cells are recruited to the juxtaglomerular area and differentiate to new renin-expressing cells. Given the proximity of macula densa to the juxtaglomerular area and the importance of macula densa released prostanoids in renin synthesis and release, we hypothesized that chronic sodium deprivation induces macula densa release of prostanoids, stimulating renal CD44+ cell activation and differentiation. CD44+ cells were isolated from adult kidneys and cocultured with the macula densa cell line, MMDD1, in normal or low-sodium medium. Low sodium stimulated prostaglandin E2 production by MMDD1 and induced migration of CD44+ cells. These effects were inhibited by addition of a cyclooxygenase 2 inhibitor (NS398) or an E-prostanoid receptor 4 antagonist (AH23848) to MMDD1 or CD44+ cells, respectively. Addition of prostaglandin E2 to CD44+ cells increased cell migration and induced renin expre...Continue Reading

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Citations

Jan 31, 2018·Nature Reviews. Nephrology·R Ariel Gomez, Maria Luisa S Sequeira-Lopez
Mar 18, 2015·Hypertension·János Peti-Peterdi
Dec 15, 2015·Physiology·R Ariel Gomez, Maria Luisa S Sequeira-Lopez
Jun 19, 2017·Pflügers Archiv : European journal of physiology·Armin Kurtz
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
May 21, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Alexandre Góes Martini, A H Jan Danser
Aug 16, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Marie-Christin SchulzGerald Schwerdt

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