Salt-sensitive hypertension in (mREN-2)27 transgenic rats

Hypertension
M F CallahanM Morris

Abstract

The (mREN-2)27 transgenic model of hypertension was developed to investigate the effect of genetic over activity of angiotensin II systems as a contributing factor in the development of arterial hypertension. In this model, transgene-positive rats demonstrate elevated renin-angiotensin system activity not only in the circulatory system but also in adrenal gland, reproductive organs, and brain. Since evidence indicates that angiotensin peptides and osmotic stimuli interact synergistically to produce exaggerated behavioral, endocrine, and cardiovascular effects, we examined the effect of salt consumption on arterial pressure, plasma vasopressin, and body fluid balance in male (mREN-2)27 transgene-positive and -negative rats. Four days of drinking 2% NaCl increased mean arterial pressure from 165 +/- 10 to 199 +/- 7 mm Hg in transgene-positive rats. In contrast, transgene-negative rats showed no change in arterial pressure (126 +/- 5 to 128 +/- 3 mm Hg). Plasma vasopressin levels were significantly elevated only in transgene-positive rats, whereas pituitary levels of vasopressin were significantly lower in transgene-positive rats compared with transgene-negative controls (18 +/- 3 and 118 +/- 14 ng, respectively). Although transge...Continue Reading

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Citations

Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Nancy R Cook
Jan 1, 2014·Journal of Public Health Management and Practice : JPHMP·Cheryl A M Anderson
Sep 22, 2005·Clinical and Experimental Pharmacology & Physiology·Janet M Ledingham, Nick Ashton
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May 15, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mariapina PomilioFrancesco Chiarelli
Mar 29, 2008·Vascular Pharmacology·Zdenka VernerováIvana Vanecková
Jun 30, 2006·Vascular Pharmacology·Ivana VaneckováLudek Cervenka
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Jun 22, 2006·American Journal of Physiology. Renal Physiology·Adam T Whaley-ConnellJames R Sowers
Feb 10, 1999·The American Journal of Physiology·P LiM Morris

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