Salt sensitivity in genetically hypertensive rats of the Lyon strain

Kidney International
M FlorinJ Sassard

Abstract

Genetically hypertensive (LH) rats of the Lyon strain exhibit a blunted pressure-natriuresis function when compared, in acute conditions, with their normotensive (LN) and low blood pressure (LL) controls. The present work was aimed to determine whether LH rats were salt sensitive in chronic conditions. In addition, a protocol was developed to determine the renal function curve in freely moving rats. Fourteen-week-old rats either untreated or orally treated since weaning with perindopril (3 mg/kg/24 h), an angiotensin-converting enzyme inhibitor, or with valsartan (15 mg/kg/24 h), an angiotensin II subtype 1 receptor antagonist, so as to eliminate the influence of endogenous changes in angiotensin formation were used. Blood pressure (BP) and urinary sodium excretion were measured before, during an oral salt load (2% NaCl in drinking water), and during a two-week aldosterone infusion (50 microg/kg/24 h subcutaneously). NaCl induced a greater BP increase in untreated LH rats than in LN and LL controls. Perindopril normalized the BP of LH rats but not its elevation during a salt load. Aldosterone slightly increased BP in LH and LL rats either untreated or treated with valsartan. Finally, the combination of telemetric BP measurement...Continue Reading

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Citations

Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Kiao Ling LiuJean Sassard
May 23, 2009·Journal of Hypertension·Sophie GilibertAnne E Kwitek
May 21, 2009·Journal of Hypertension·Juan M Saavedra
Jun 2, 2017·Physiological Reviews·Bernardo Rodriguez-IturbeRichard J Johnson
Jul 23, 2016·Hypertension·Fernando ElijovichUNKNOWN American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional
Oct 20, 2018·Nature Reviews. Nephrology·Alan Kim Johnson, Baojian Xue
Nov 26, 2010·Journal of Cardiovascular Pharmacology·Gaëlle NaeltenMing Lo
May 17, 2005·Journal of Hypertension·Chao-Yu MiaoJean Sassard
Apr 4, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah C ClaytonAlan Kim Johnson
Jan 17, 2003·American Journal of Physiology. Renal Physiology·Albert SarkisDaniel Benzoni
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan Kim JohnsonBaojian Xue

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