Abstract
Genetically hypertensive (LH) rats of the Lyon strain exhibit a blunted pressure-natriuresis function when compared, in acute conditions, with their normotensive (LN) and low blood pressure (LL) controls. The present work was aimed to determine whether LH rats were salt sensitive in chronic conditions. In addition, a protocol was developed to determine the renal function curve in freely moving rats. Fourteen-week-old rats either untreated or orally treated since weaning with perindopril (3 mg/kg/24 h), an angiotensin-converting enzyme inhibitor, or with valsartan (15 mg/kg/24 h), an angiotensin II subtype 1 receptor antagonist, so as to eliminate the influence of endogenous changes in angiotensin formation were used. Blood pressure (BP) and urinary sodium excretion were measured before, during an oral salt load (2% NaCl in drinking water), and during a two-week aldosterone infusion (50 microg/kg/24 h subcutaneously). NaCl induced a greater BP increase in untreated LH rats than in LN and LL controls. Perindopril normalized the BP of LH rats but not its elevation during a salt load. Aldosterone slightly increased BP in LH and LL rats either untreated or treated with valsartan. Finally, the combination of telemetric BP measurement...Continue Reading
References
Jun 1, 1977·Canadian Journal of Physiology and Pharmacology·A C DarkeP Gaskell
Jun 1, 1992·Hypertension·I A MedeirosJ Sassard
Dec 1, 1991·Hypertension·V M CampeseR Bigazzi
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·B P BrockwayS H Azar
Sep 1, 1990·Journal of Hypertension·N J SamaniJ D Swales
Jul 1, 1990·Hypertension·M LoJ Sassard
Jan 1, 1990·Computers in Biology and Medicine·M P GustinC Z Paultre
Jan 1, 1988·Pharmacology·J T Knape, P A van Zwieten
Sep 1, 1986·The American Journal of Medicine·N K HollenbergG H Williams
Nov 15, 1972·Experientia·D Ben-IshayA Welner
Sep 1, 1980·The American Journal of Medicine·T FujitaC S Delea
Jun 1, 1995·Hypertension·J P Rapp, A Y Deng
Apr 1, 1994·Hypertension·V M Campese
Jun 1, 1994·Hypertension·J M WyssK H Berecek
Mar 1, 1996·Hypertension·M H Weinberger
Feb 1, 1997·The American Journal of Clinical Nutrition·A W Cowley
Mar 1, 1997·Hypertension·A OnoT Fujita
Dec 31, 1997·The American Journal of the Medical Sciences·M S MozaffariJ M Wyss
Feb 1, 1997·Journal of Hypertension·S GründerB C Rossier
Jan 16, 1999·Journal of Cardiovascular Pharmacology·A L Le RoyD Benzoni
May 8, 1999·American Journal of Hypertension·I Messer-LétienneD Benzoni
Nov 24, 1999·Hypertension·S A Lloyd-MacGilpC J Kenyon
May 5, 1962·Nature·L K DAHLL TASSINARI
May 5, 1962·Nature·J P PAYNE, C M CONWAY
Citations
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Kiao Ling LiuJean Sassard
May 23, 2009·Journal of Hypertension·Sophie GilibertAnne E Kwitek
May 21, 2009·Journal of Hypertension·Juan M Saavedra
Oct 29, 2008·Acta Pharmacologica Sinica·Eleanor J EganJean Sassard
May 2, 2013·Clinical and Experimental Hypertension : CHE·Güngör KanbakHakan Şentürk
Apr 30, 2008·American Journal of Hypertension·Léa EmonnotMing Lo
Jun 2, 2017·Physiological Reviews·Bernardo Rodriguez-IturbeRichard J Johnson
Jul 23, 2016·Hypertension·Fernando ElijovichUNKNOWN American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional
Aug 10, 2017·PloS One·Man Chun John MaAnne E Kwitek
Oct 20, 2018·Nature Reviews. Nephrology·Alan Kim Johnson, Baojian Xue
Nov 26, 2010·Journal of Cardiovascular Pharmacology·Gaëlle NaeltenMing Lo
Jan 11, 2007·Journal of Hypertension·Léa EmonnotMing Lo
May 17, 2005·Journal of Hypertension·Chao-Yu MiaoJean Sassard
Nov 25, 2005·Journal of Cardiovascular Pharmacology·Gaëlle NaeltenMing Lo
Apr 4, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah C ClaytonAlan Kim Johnson
Feb 21, 2008·Physiological Genomics·S GilibertA Bataillard
Jan 17, 2003·American Journal of Physiology. Renal Physiology·Albert SarkisDaniel Benzoni
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan Kim JohnsonBaojian Xue