Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension

Hypertension
C YagilY Yagil

Abstract

Random genome screening was initiated in the Sabra rat model of hypertension in search of genes that account for salt sensitivity or salt resistance in terms of the development of hypertension. Female salt-sensitive Sabra hypertension-prone (SBH/y) rats were crossed with male salt-resistant Sabra hypertension-resistant (SBN/y) rats, resulting in an F2 cohort consisting of 100 males and 132 females. Systolic blood pressure (BP) was measured in rats at 6 weeks of age under basal conditions and after 4 weeks of salt loading. Genotypes for 24 polymorphic microsatellite markers localized to chromosome 1 and for 8 markers localized to chromosome 17 were determined in F2 and cosegregation with BP was evaluated by ANOVA and multipoint linkage analysis. Basal BP did not cosegregate with any locus on chromosomes 1 or 17. In contrast, BP after salt loading showed significant cosegregation with three QTLs, two on chromosome 1 and one on chromosome 17, designated SS1a, SS1b, and SS17, respectively; the maximal logarithm of the odds (LOD) scores were 4.71, 4.91, and 3.43, respectively. Further analysis revealed sexual dimorphism. In male F2, BP response to salt loading cosegregated with one QTL (LOD score 4.52) and a second QTL (LOD score 2....Continue Reading

References

Jan 1, 1995·Nature Genetics·H J JacobA Lernmark
Jul 1, 1994·The Journal of Clinical Investigation·A Y DengJ P Rapp
Apr 1, 1993·American Journal of Hypertension·E L HarrisJ P Rapp
Feb 1, 1996·The Journal of Clinical Investigation·L GuJ P Rapp

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Hypertension Reports·M Knoblauch, K Lindpaintner
Jun 1, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Angela Schulz, Reinhold Kreutz
Apr 25, 2000·Clinical and Experimental Pharmacology & Physiology·T NabikaY Yamori
Jul 14, 2010·BMC Biology·Ricardo A VerdugoJuan F Medrano
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hyoe InomataNorihiro Kato
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Noriyoshi IshikawaToru Nabika
May 26, 2001·Biochemical and Biophysical Research Communications·I KlötingJ van den Brandt
Oct 13, 2006·Nature Reviews. Genetics·Allen W Cowley
Jan 14, 1999·Journal of Hypertension·A F DominiczakM J Brosnan
Apr 13, 2012·Journal of Hypertension·Tanika N Kelly, Jiang He
Feb 14, 2006·Trends in Cardiovascular Medicine·Yoram Yagil, Chana Yagil
May 11, 2005·American Journal of Hypertension·Alanna C MorrisonRobert E Ferrell
Jan 13, 2005·American Journal of Physiology. Renal Physiology·David L MattsonAllen W Cowley
Sep 12, 2000·Current Hypertension Reports·G T Cicila
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Maria João PinhoPatrício Soares-da-Silva
Jan 11, 2007·Physiological Genomics·Chana YagilYoram Yagil
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Mostafa KhalidJean-Pierre Dausse
Apr 7, 2006·American Journal of Physiology. Renal Physiology·Michiaki AbeAllen W Cowley
Feb 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen W Cowley
Jan 5, 2000·Physiological Reviews·J P Rapp
Jan 5, 2006·Physiological Genomics·Chana YagilYoram Yagil
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y TsujitaM Kinoshita
Oct 9, 2003·Physiological Genomics·Carol MorenoAllen W Cowley
Jun 5, 2002·Physiological Genomics·Chana YagilYoram Yagil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.