Salting-out assisted liquid-liquid extraction for the determination of ciprofloxacin residues in water samples by high performance liquid chromatography-diode array detector

BMC Chemistry
Teshome GezahegnBhagwan Singh Chandravanshi

Abstract

The occurrence of emerging pollutants like pharmaceuticals and related compounds in the aquatic and terrestrial environments is of increasing concern. Ciprofloxacin is one of the pharmaceuticals which is active against a wide range of bacteria. The main objective of this research is to develop a simple method for the extraction and determination of ciprofloxacin residues in environmental water samples. A salting-out assisted liquid-liquid extraction (SALLE) method for the determination of ciprofloxacin in water samples by high-performance liquid chromatography with diode array detector (HPLC-DAD) was developed. The calibration curve was linear over the range of 0.1-100 μg/L with coefficient of determination (r2) of 0.9976. The limits of detection (LOD) and quantification (LOQ) of the method were 0.075 and 0.25 µg/L, respectively. The reproducibility in terms of relative standard deviation (% RSD) was less than 10%. The applicability of the developed method was investigated by analyzing tap water, bottled mineral water and waste water and demonstrated satisfactory recoveries in the ranges of 86.4-120%. The method offered a number of features including wide linear range, good recovery, short analysis time, simple operation proces...Continue Reading

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Citations

Aug 5, 2020·Critical Reviews in Analytical Chemistry·Seyed Amin KhatibiMohammad Reza Siahi-Shadbad
Feb 24, 2020·Analytical and Bioanalytical Chemistry·Guilaine JariaValdemar I Esteves
Sep 3, 2021·Journal of Separation Science·Sherin F HammadFotouh R Mansour
Nov 29, 2021·Journal of Separation Science·Verónica HernandisPedro Marín

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Software Mentioned

SPSS
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