SALTIRE-RAAVE: targeting calcific aortic valve disease LDL-density-radius theory

Expert Review of Cardiovascular Therapy
Nalini M RajamannanKristian Wachtell

Abstract

SALTIRE and RAAVE were the first two studies to evaluate the use of statin therapy for impeding calcific aortic valve disease (CAVD). This review presents the findings of low-density lipoprotein (LDL)-density-radius theory as tested using the combined results from the SALTIRE and RAAVE studies. Patients who received statin therapy had a greater degree of LDL cholesterol lowering, seen as the % change in LDL (47 vs 2%, p = 0.012), which in itself was significantly associated with a lesser change in aortic valve area (AVA; p < 0.001 and R(2) = 0.27). The percent change in the AVA for the treated patients was 5% and 15% for the nontreated patients (p = 0.579 and R(2) = 0.03). In summary, these published findings suggest that when applying the LDL-density-radius theory, which combines the cellular biology and the hemodynamics as defined by the continuity equation for AVA, there may be a role for lipid-lowering therapy in contemporary patients with calcific aortic valve disease (CAVD).

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Citations

Dec 25, 2015·Journal of the American College of Cardiology·Nalini M Rajamannan
Dec 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ana M PorrasKristyn S Masters
Feb 25, 2020·Physiological Genomics·Alexander P KossarGiovanni Ferrari
Apr 23, 2020·Expert Review of Cardiovascular Therapy·Nalini M RajamannanPatricia Best
May 22, 2019·Scandinavian Cardiovascular Journal : SCJ·Johan LjungbergStefan Söderberg

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