Abstract
Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg(-1) 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg(-1) salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific ap...Continue Reading
References
Jul 1, 1988·Cardiovascular Research·M J WalkerD W Harron
Nov 1, 1983·Canadian Journal of Physiology and Pharmacology·K M JohnstonM J Walker
Jun 1, 1980·Journal of Pharmacological Methods·C ClarkJ R Parratt
Mar 21, 2002·Journal of Cardiovascular Pharmacology·Li Lin, Wen-Jun Yuan
Aug 12, 2003·Nature Medicine·Masayoshi ShichiriYukio Hirata
Oct 20, 2004·Regulatory Peptides·Fang YuLin Chang
Feb 9, 2005·Hypertension·Hajime IzumiyamaMasayoshi Shichiri
Jun 15, 2005·Annual Review of Biochemistry·Martin Schröder, Randal J Kaufman
Oct 4, 2005·The Journal of Clinical Investigation·Chunyan XuJohn C Reed
Jan 7, 2006·Cell Death and Differentiation·M Boyce, J Yuan
Jun 24, 2006·Circulation Research·Donna J ThueraufChristopher C Glembotski
Aug 8, 2006·Peptides·Kengo SatoMasayoshi Shichiri
Sep 7, 2006·Journal of Cardiovascular Pharmacology·Yan Xiao-HongYuan Wen-Jun
Sep 19, 2006·Biochemical and Biophysical Research Communications·Eva SzegezdiAfshin Samali
Jun 8, 2007·Nature Medicine·Sheila M GardinerTerence Bennett
Dec 1, 2007·Journal of Neuroendocrinology·T SaitoY Ueta
Aug 16, 2008·Experimental Biology and Medicine·Cuihong HanXuejun Sun
Jul 23, 2009·The Journal of Biological Chemistry·Shirin DoroudgarChristopher C Glembotski
Jul 31, 2009·Cardiovascular Research·M A Hassan TalukderMuthu Periasamy
Aug 8, 2009·Regulatory Peptides·Kengo SatoMasayoshi Shichiri
Mar 24, 2010·Peptides·Jing-Song ShiAn-Jing Ren
Nov 13, 2010·Circulation Research·Jody GroenendykMarek Michalak
Jan 5, 2011·Peptides·Noriko SuzukiYukio Hirata
Citations
Oct 17, 2013·Heart and Vessels·Qifeng ZhaoJie Xia
Aug 21, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S Aydin, S Aydin
Sep 17, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Ayhan TanyeliTuğba Bal
Oct 19, 2017·International Journal of Molecular Sciences·Yuanyuan ZhangZhou Zhang
Mar 3, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mengmeng GongYidong Wei