Salvage pathways in glycosphingolipid metabolism

Biochimie
G TettamantiL Riboni

Abstract

In this review, the focus is on the role of salvage pathways in glycosphingolipid, particularly, ganglioside metabolism. Ganglioside de novo biosynthesis, that begins with the formation of ceramide and continues with the sequential glycosylation steps producing the oligosaccharide moieties, is briefly outlined in its enzymological and cell-topological aspects. Neo-synthesized gangliosides are delivered to the plasma membrane, where their oligosaccharide chains protrude toward the cell exterior. The metabolic fate of gangliosides after internalization via endocytosis is then described, illustrating: (a) the direct recycling of gangliosides to the plasma membrane through vesicles gemmated from sorting endosomes; (b) the sorting through endosomal vesicles to the Golgi apparatus where additional glycosylations may take place; and (c) the channelling to the endosomal/lysosomal system, where complete degradation occurs with formation of the individual sugar (glucose, galactose, hexosamine, sialic acid) and lipid (ceramide, sphingosine, fatty acid) components of gangliosides. The in vivo and in vitro evidence concerning the metabolic recycling of these components is examined in detail. The notion arises that these salvage pathways, le...Continue Reading

References

Apr 28, 1978·Biochimica Et Biophysica Acta·G Schwarzmann
Dec 11, 1992·Biochimica Et Biophysica Acta·D Hoekstra, J W Kok
Mar 1, 1992·The Journal of Cell Biology·R D KlausnerJ Lippincott-Schwartz
Nov 15, 1989·Biochemical and Biophysical Research Communications·Y Igarashi, S Hakomori
Jan 1, 1989·Annual Review of Cell Biology·G van Meer
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J W KokD Hoekstra
Jul 1, 1986·The Biochemical Journal·R GhidoniG Tettamanti
Jun 28, 1972·Biochemical and Biophysical Research Communications·H DiringerF A Anderer
Dec 12, 1972·Brain Research·G TettamantiP Mandel
Sep 1, 1971·Biochemical Pharmacology·K MasekH W Felsenfeld
Oct 1, 1969·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W StoffelG Sticht
Jan 1, 1983·The Journal of Cell Biology·R M SteinmanZ A Cohn
Jan 1, 1981·Annual Review of Biochemistry·S Hakomori
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S Schulte, W Stoffel

❮ Previous
Next ❯

Citations

Oct 18, 2012·Cancer Chemotherapy and Pharmacology·Melis Kartal YandımYusuf Baran
Jan 9, 2009·Journal of Inherited Metabolic Disease·S U Walkley
Aug 4, 2010·Neuromolecular Medicine·Yanfeng ChenAlfred H Merrill
Dec 14, 2012·Nature Reviews. Cancer·Samy A F Morad, Myles C Cabot
Jul 29, 2005·Nature Reviews. Neuroscience·Mylvaganam JeyakumarFrances M Platt
Jan 7, 2006·Cell Death and Differentiation·A d'AzzoR Sano
Feb 1, 2012·The Journal of Biological Chemistry·Nadine Hagen-EuteneuerGerhild van Echten-Deckert
Mar 13, 2009·The Journal of Biological Chemistry·Kazuyuki KitataniYusuf A Hannun
Apr 20, 2011·Cold Spring Harbor Perspectives in Biology·Heike Schulze, Konrad Sandhoff
Feb 26, 2010·Journal of Virology·Alyson I SwimmDaniel Kalman
Mar 9, 2013·Journal of Lipid Research·Maria Laura MartinGwendolyn Barceló-Coblijn
Mar 10, 2010·Journal of Lipid Research·You-Hai XuGregory A Grabowski
Jan 31, 2014·Brain : a Journal of Neurology·Karen E MurphyGlenda M Halliday
Mar 15, 2014·International Journal of Molecular Sciences·Paola GiussaniBruno Venerando
Oct 3, 2014·Gene·Maria Francisca CoutinhoSandra Alves
May 8, 2007·Carbohydrate Research·José Antonio Morales-SernaSergio Castillón
Oct 10, 2008·Organic & Biomolecular Chemistry·José Antonio Morales-SernaSergio Castillón
Apr 27, 2012·The Journal of Organic Chemistry·Karell Pérez-LabradaDaniel G Rivera
Oct 1, 2015·Molecular Genetics and Metabolism·Maria Francisca Coutinho, Sandra Alves
Oct 20, 2009·FEBS Letters·Thomas Kolter, Konrad Sandhoff
Jul 29, 2015·International Journal for Parasitology·Sebastian DamerowFrançoise H Routier
Nov 5, 2013·Biochimica Et Biophysica Acta·Heike Schulze, Konrad Sandhoff
Nov 5, 2013·Biochimica Et Biophysica Acta·Auxiliadora Aguilera-RomeroHoward Riezman
Jan 9, 2016·Neurochemistry International·Melinda BarkhuizenAnne F Grobler
May 22, 2007·FEBS Letters·Cristina LimatolaAngelo Spinedi
Oct 12, 2007·Trends in Biochemical Sciences·Alfred H MerrillM Cameron Sullards
Jan 15, 2008·Cellular Signalling·Kazuyuki KitataniYusuf A Hannun
Mar 8, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Renata SanoJanice C Coelho
Feb 19, 2005·Neurobiology of Aging·Marina PittoMassimo Masserini
Dec 2, 2004·Brain Research. Brain Research Reviews·Laura Colombaioni, Mercedes Garcia-Gil
Sep 8, 2010·Expert Review of Neurotherapeutics·Phyllis L FaustJames M Powers
May 23, 2015·Molecules and Cells·Kazuyuki KitataniToshiro Okazaki
Mar 30, 2007·Acta Paediatrica. Supplement·Steven U Walkley
May 14, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah K AbbottBrett Garner
Jul 26, 2015·Metabolic Brain Disease·Marta MoskotMagdalena Gabig-Cimińska
Jun 1, 2007·Expert Opinion on Drug Discovery·Norman S Radin
Feb 11, 2015·Biochimica Et Biophysica Acta·Frédérique SabourdyThierry Levade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
Mahua Chakraborty, Xian-Cheng Jiang
Journal of Neurochemistry
Hugo J F MaccioniMariana L Ferrari
© 2022 Meta ULC. All rights reserved