Salvage prostate brachytherapy for localized prostate cancer failure after external beam radiation therapy

Brachytherapy
Hoon K LeeJoseph Motta

Abstract

To determine the toxicity and clinical outcome of salvage prostate brachytherapy for localized prostate cancer failure after external beam radiation therapy. Twenty-one patients underwent (103)Pd salvage brachytherapy (median minimum peripheral dose, 90Gy) after local failure after external beam radiation (median dose, 66.6Gy) from 1/21/1998 to 4/5/2005. The median age was 72 years. Six patients had prior transurethral resection of the prostate. The median Gleason score was 7 and the median preimplant prostate-specific antigen was 3.8. Twelve patients received concurrent androgen ablation with prostate brachytherapy. Biochemical failure was defined as three consecutive rises in prostate-specific antigen scored at the call date, initiation of hormone therapy, or clinical failure. Toxicity was defined according to the National Cancer Institute common toxicity criteria and the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring scheme. With a median followup of 36 months, the actuarial 3-year and 5-year overall survival rates were 81% and 81%, and the biochemical failure-free survival rates were 94% and 38%, respectively. There was no significant difference i...Continue Reading

References

Mar 1, 1997·The Journal of Urology·L L PistersR J Babaian
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G K Zagars, A Pollack
Jul 20, 1999·The Journal of Urology·P PerrotteL L Pisters
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan I IzawaLouis L Pisters
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Alan PollackIsaac Rosen
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Michael J ZelefskySteven A Leibel
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Michael J ZelefskyMarco Zaider
Jun 20, 2003·The New England Journal of Medicine·Mukesh G HarisinghaniRalph Weissleder
Dec 18, 2003·BJU International·K-R Han, A S Belldegrun
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Fernando J BiancoJames A Eastham
Jul 5, 2005·Urology·Gregory S MerrickWayne M Butler
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J Stephenson, James A Eastham

❮ Previous
Next ❯

Citations

Oct 12, 2012·World Journal of Urology·Stephen J Ramey, David T Marshall
Oct 15, 2008·Prostate Cancer and Prostatic Diseases·V ChalasaniJ Chin
Dec 23, 2011·Radiology·Hebert Alberto VargasHedvig Hricak
Nov 10, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Emmie KaljouwPeter J Hoskin
Mar 12, 2013·International Journal of Radiation Oncology, Biology, Physics·Chien Peter ChenI-Chow Hsu
Jan 27, 2010·Cancer Treatment Reviews·Christian Boukaram, Jean-Michel Hannoun-Levi
Feb 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Ryan J BurriRichard G Stock
May 12, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Piotr WojcieszekMarek Fijałkowski
Sep 11, 2020·Expert Review of Anticancer Therapy·Francesco CucciaFilippo Alongi
Aug 5, 2020·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Guglielmo ManticaUNKNOWN ESRU (European Society of Residents in Urology)
Dec 15, 2016·Brachytherapy·Brian J DavisNeha Vapiwala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.