Salvage radical prostatectomy after external beam radiation therapy: a systematic review of current approaches

Urologia Internationalis
Deliu Victor MateiOttavio De Cobelli

Abstract

Radical external beam radiotherapy (EBRT) is a standard treatment for prostate cancer patients. Despite this, the rate of intraprostatic relapses after primary EBRT is still not negligible. There is no consensus on the most appropriate management of these patients after EBRT failure. For these patients, local salvage therapy such as radical prostatectomy, cryotherapy, and brachytherapy may be indicated. The objectives of this review were to analyze the eligibility criteria for careful selection of appropriate patients and to evaluate the oncological results and complications for each method. A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. Most studies demonstrated that local salvage therapy after EBRT may provide long-term local control in appropriately selected patients, although toxicity is often significant. Our results suggest that for localized prostate cancer recurrence after EBRT, the selection of a local treatment modality should be made on a patient-by-patient basis. An improvement in selection criteria and an integrated definition of biochemical failure for all salvage methods are required to determine which p...Continue Reading

Citations

Oct 6, 2015·Future Oncology·Catherine Hanna, Robert J Jones
May 8, 2016·Urology·Estefania Linares EspinósXavier Cathelineau
Dec 23, 2016·Der Urologe. Ausg. A·Y Tolkach, G Kristiansen
Apr 24, 2017·Current Treatment Options in Oncology·Farhad FakhrejahaniWilliam L Dahut
Apr 30, 2021·Prostate International·Pablo F MartinezWenceslao A Villamil
May 10, 2021·Cancer Treatment Reviews·Barbara A Jereczek-FossaUNKNOWN on the behalf of the European Society for Radiotherapy, Oncology Advisory Committee on Radiation Oncology Practice (ESTRO AC
Jul 1, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicole SchönleRainer Fietkau

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