Salvage radical prostatectomy after failure of curative radiotherapy for adenocarcinoma of prostate

Urology
A SteinJ B deKernion

Abstract

Radical prostatectomy with curative intent was performed in 13 patients with prostate cancer after local failure of radiotherapy. Of these patients, 2 underwent cystoprostatectomy for bladder neck involvement by the prostatic tumor. Local recurrence had been diagnosed twenty-one to one hundred sixty-eight months (mean 65.4 months) after completion of radiotherapy (6,000-7,000 cGy; mean 6,136 cGy). Three patients had radioactive implants. Rising prostate-specific antigen (PSA) was part of the indication for surgery in 5 patients. Complications included minor rectal injury (1 patient) and total incontinence (2/13 patients). Two patients had positive surgical margins and 6/13 patients had involvement of seminal vesicles, 2 of whom also had positive lymph nodes. The authors conclude that salvage prostatectomy is feasible after radiation failure. Transrectal ultrasound and careful monitoring of PSA after irradiation treatment may improve patient selection and minimize the risk of complications and incomplete excision.

Citations

Sep 20, 2006·Der Urologe. Ausg. A·R E Hautmann
Sep 3, 2004·Current Treatment Options in Oncology·Andrew J StephensonJames A Eastham
May 9, 2003·The Urologic Clinics of North America·Nancy B DavisNicholas J Vogelzang
Nov 1, 1996·The Urologic Clinics of North America·D A CorralA C von Eschenbach
Sep 10, 2003·Current Problems in Cancer·Judd W Moul
Mar 3, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C C Parker, D P Dearnaley
Nov 13, 2003·Postgraduate Medical Journal·S R J BottR S Kirby
Jan 12, 2005·The Journal of Urology·Naji J ToumaJoseph L Chin
May 8, 2000·The Journal of Urology·J W Moul
Nov 4, 2000·The Journal of Urology·A Vaidya, M S Soloway
Oct 10, 2001·The Urologic Clinics of North America·B ShekarrizJ E Pontes
Nov 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J Stephenson, James A Eastham
Mar 19, 2005·Technology in Cancer Research & Treatment·Joseph L Chin, Naji Touma
Oct 9, 2003·The Journal of Urology·Guy VallancienFrançois Rozet
Dec 8, 2004·Prostate Cancer and Prostatic Diseases·S AhmedJ Davies
Feb 1, 1997·Scandinavian Journal of Urology and Nephrology·R F TalicP Ekman
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L L PistersA C von Eschenbach

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