Abstract
Definitive chemoradiotherapy (dCRT) is the first choice treatment for patients with locally advanced non-small cell lung cancer (NSCLC), but up to 35% of dCRT-treated tumors may have persistent or recurrent disease. Since the last decades, multimodality therapy showing potential for cure has become the mainstream for treatment of locally advanced NSCLCs, even some that were initially inoperable. Although salvage lung resection after dCRT has been reported with acceptable survivals, experiences in this respect are still limited. Other concerns remain debatable and inconclusive, such as dosage of radiation exposure, long interval between dCRT and surgery, and surgical comorbidity. A 73-year-old male former smoker with diagnosis of right lower lobe of lung squamous cell carcinoma (SqCC) with multiple mediastinal lymphadenopathy, cT4N2M0, stage IIIB, received salvage right lower lobe + right middle lobe bilobectomy through video-assisted thoracoscopic surgery (VATS) after dCRT and adjuvant CRT to a total of 9000 cGy dosage of radiation. The interval from the 1st and 2nd ends of radiation to the salvage surgery was 980 and 164 days, respectively. The pre-operative forced expiratory volume in the first second was 2.33 L (101% predict...Continue Reading
References
Oct 13, 1998·The Annals of Thoracic Surgery·P H HollausN S Pridun
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Alena Novakova-JiresovaRobert P Coppes
Dec 4, 2008·The Annals of Thoracic Surgery·Julie E BaumanDouglas E Wood
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Apr 6, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gregory A KuzmikAnthony W Kim
Apr 19, 2015·The Annals of Thoracic Surgery·Chi-Fu Jeffrey YangMark F Berry
Dec 15, 2015·Cancer Letters·Hongbo GuoJinming Yu
Jan 20, 2016·Journal of Cardiothoracic Surgery·Waldemar SchreinerHoria Sirbu
Aug 22, 2017·Seminars in Thoracic and Cardiovascular Surgery·Monica CasiraghiLorenzo Spaggiari
Nov 14, 2019·Surgical Case Reports·Ping-Chung TsaiChao-Hua Chiu
May 31, 2020·The Annals of Thoracic Surgery·Adam J BogradEric Vallières
Aug 17, 2020·The Journal of Thoracic and Cardiovascular Surgery·Jessica S DoningtonUNKNOWN NRG Oncology Lung Group
Feb 12, 2021·Translational Lung Cancer Research·Akira HamadaTetsuya Mitsudomi