Salvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol.

Systematic Reviews
Ashley A AdileAdam J Fleming

Abstract

Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. Therefore, a systematic review of the literature regarding treatment strategies employed in recurrent pediatric MB will evaluate previous salvage therapies in order to guide future clinical trials. The aim of this systematic review will be to investigate the efficacy and safety of salvage therapies for the management of children with progressive, treatment-refractory, or recurrent MB. We will conduct literature searches (from 1995 onwards) in MEDLINE, EMBASE, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and Cochrane Central Register of Controlled Trials. Studies examining the survival and toxicity of therapies administered to treatment-refractory pediatric MB patients will be included. Two reviewers will independently assess the search results based on predefined selection criteria, complet...Continue Reading

References

Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L WhiteK Tiedemann
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M ZeltzerR J Packer
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger E TaylorUNKNOWN United Kingdom Children's Cancer Study Group
Jan 31, 2006·Neuro-oncology·David S ZieglerUNKNOWN Australian and New Zealand Children's Study Group
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger J PackerRichard Sposto
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Nov 13, 2008·Archives of Neurology·Roger J Packer, Gilbert Vezina
Jun 29, 2011·Nature Reviews. Clinical Oncology·Ching-Hon PuiAlberto S Pappo
Jun 30, 2011·Deutsches Ärzteblatt International·Michael C Frühwald, Stefan Rutkowski
Aug 26, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Canan AkyüzMünevver Büyükpamukçu
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 22, 2012·Nature·Xiaochong WuMichael D Taylor
Nov 24, 2012·Nature Reviews. Cancer·Paul A NorthcottStefan M Pfister
Jan 9, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dolly AguileraRobert C Castellino
Sep 10, 2014·Current Treatment Options in Oncology·Allison M MartinKenneth J Cohen
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Jan 14, 2016·Nature·A Sorana MorrissyMichael D Taylor
Mar 24, 2016·BMC Medical Research Methodology·Timor FaberAgnes Dechartres
Oct 14, 2016·BMJ : British Medical Journal·Jonathan Ac SterneJulian Pt Higgins
Nov 1, 2016·Anticancer Research·Carsten NiederAnca L Grosu
Oct 27, 2017·Brain Sciences·Elias J Sayour, Duane A Mitchell
Feb 1, 2018·Implementation Science : IS·Simon LewinJane Noyes
Sep 27, 2018·Journal of Clinical Epidemiology·Richeek PradhanHong Yu
Nov 6, 2018·Clinical Oncology : a Journal of the Royal College of Radiologists·D S Tsang, N J Laperriere
Aug 30, 2019·BMJ : British Medical Journal·Jonathan A C SterneJulian P T Higgins

❮ Previous
Next ❯

Citations

Sep 11, 2021·Journal of Neuro-oncology·Lorena V BaroniDaniel Alderete

❮ Previous
Next ❯

Software Mentioned

Cochrane
ROBINS
Stata SE
CERQual
Cochrane Risk of Bias RoB
GRADE
- I
robvis
Review Manager ( RevMan )
Covidence

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuro-oncology
Tobey J MacDonaldRobert C Castellino
Current Treatment Options in Oncology
Nazanin Majd, Marta Penas-Prado
The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Michelle M Kameda-SmithPediatric Brain Tumour Study Group
© 2021 Meta ULC. All rights reserved