Salvage therapy outcomes for atypical meningioma

Journal of Neuro-oncology
William C ChenSteve E Braunstein

Abstract

Atypical menginomas demonstrate increased clinical aggressiveness characterized by recurrence and diminished survival. The optimal management of atypical meningioma in the recurrent setting is especially not well defined. To characterize outcomes following salvage treatment of recurrent atypical meningioma and to identify risk factors for further recurrence. Retrospective chart review was performed on 65 patients who underwent salvage treatment of atypical meningioma at a single institution. Data were analyzed using the Kaplan-Meier method and Cox proportional hazards modeling. Sixty-five patients with recurrent atypical meningioma and median imaging follow-up of 4.0 years (range 1.9-6.6 years) underwent 62 surgeries and 114 radiation treatments (RT) for salvage therapy. Salvage modality was surgery (21%), surgery/RT (25%), or RT alone (54%), associated with 2 year local freedom from recurrence (LFFR) of 36, 59, and 73%, respectively (P = 0.01). Twenty percent of patients experienced CTCAE grade ≥ 3 toxicity with salvage therapy. Thirty-nine percent of patients experienced ≥ 3 recurrences. The median disease-free survival intervals after first and second salvage treatments were 2.9 and 1.3 years, respectively. On univariate Cox...Continue Reading

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Citations

Sep 29, 2018·Journal of Neurosurgery·José Pedro LavradorRanjeev Bhangoo
Jan 17, 2019·Neuro-oncology·Priscilla K BrastianosUNKNOWN International Consortium on Meningiomas
Apr 20, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sukwoo HongHideki Ogiwara
Jul 31, 2019·Radiation Oncology·Kerstin ZwirnerFranziska Eckert
Aug 11, 2020·International Journal of Radiation Oncology, Biology, Physics·Grace LeeHelen A Shih
Jun 3, 2021·British Journal of Neurosurgery·Mônica Schuring-PereiraRuud Wiggenraad

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