Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia

Planta medica
Jin Kyu KimYongmun Choi

Abstract

Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered thatSalvia plebeiaextract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia,S. plebeiaextract reduced serum urate to the levels observed in control animals. The urate-lowering effect ofS. plebeiaextractin vivowas supported by the identification of compounds that inhibit xanthine oxidase enzyme activityin vitro. Nepetin, scutellarein, and luteolin contributed significantly toS. plebeiabioactivityin vitro. These compounds showed the highest potency against xanthine oxidase with IC50values of 2.35, 1.74, and 1.90 µM, respectively, and were present at moderate quantities. These observations serve as a basis for further elaboration of theS. plebeiaextracts for the development of new therapeutics for hyperuricemia and related diseases.

Citations

May 17, 2019·Archives of Physiology and Biochemistry·Walid Hamdy El-Tantawy
Dec 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olívia R PereiraSusana M Cardoso
Jul 17, 2020·Frontiers in Pharmacology·Shyh-Shyun HuangJung Chao
Apr 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Rong TangHong Liu

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