Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses

Neuroscience Letters
Zhihui DongGang Yao

Abstract

Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), is a Th1 and Th17 cell-mediated CNS autoimmune disease. Therefore, immune regulation is a key target for therapy. Salvianolic acid B (Sal B) is a major water-soluble bioactive component of the famous traditional Chinese medicine Salvia miltiorrhiza, which is notable for its anti-oxidative and anti-inflammatory effects. Thus Sal B, by impairing Th1 or Th17 responses in EAE/MS, might ameliorate the crippling symptoms. Here we show that the intraperitoneal administration of 30mg/kg Sal B daily for 14 days after the onset of MOG-induced EAE in mice effectively reduced its severity. Additionally, Sal B treatment downgraded the infiltration of inflammatory cells, limited astrogliosis and blocked Th1 responses other than that of Th17. These results indicated that Sal B may serve as an effective therapeutic agent for MS/EAE by inhibiting Th1 cell responses.

References

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Citations

Jun 2, 2017·Phytotherapy Research : PTR·Majid Asadi-SamaniHedayatollah Shirzad
Sep 20, 2020·Pharmaceutics·Norwin KubickMichel-Edwar Mickael
Aug 4, 2019·Neurochemistry International·Leila MohtashamiBehjat Javadi
Jan 10, 2020·Journal of Reproductive Immunology·Jing WangXiao-Kang Li
Mar 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kai ZhongYi-Lu Ye
Dec 12, 2018·International Immunopharmacology·Shuangwen YuKaili Hu

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