Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca(2+) overload in rat cardiomyocytes

Toxicology Letters
Rong-Chang ChenXiaobo Sun

Abstract

Doxorubicin (DOX)-induced cardiotoxicity is a clinically complex syndrome that leads to significant pain to cancer survivors. Endoplasmic reticulum (ER) stress has been suggested to be an important contributor to myocardium dysfunction during this phenomenon. Our previous study proved that Salvianolic acid B (Sal B) protected against doxorubicin induced cardiac dysfunction by inhibiting ER stress and cardiomyocyte apoptosis. However, the underlying molecular mechanism is not yet clearly. In this study, we investigated the protective effect and mechanisms of Sal B againest DOX-induced cardiac injury and ER stress in vivo and in vitro. After pretreatment with Sal B (0.25, 0.5, 1mg/kg i.v.) for 7 days, male SD rats were intraperitoneally injected with a single dose of DOX (3mg/kg) every 2 days for three injections. The cardioprotective effect of Sal B was observed 2 weeks after the first administration. Adult rat ventricular myocytes were isolated and treated with Sal B (20μg/ml) for 6h and then exposed in DOX (1μm) for 4h. The cardiomyocyte contractility and the level of intracellular Ca(2+) were determined. Sal B ameliorated DOX-induced apoptosis damage in heart tissues. In vitro studies showed that DOX induced adult rat ventric...Continue Reading

References

Mar 1, 1997·The Journal of Physiology·M J Berridge
Nov 27, 1999·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·M FreichelV Flockerzi
Jan 25, 2003·Cell Calcium·Michael J Berridge
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Aug 19, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shusheng Li, Lei Wan
Aug 4, 2005·Cell Calcium·Denis BurdakovAlexei Verkhratsky
Jan 21, 2006·Journal of Cardiovascular Pharmacology·Francis Fu Yuen LamPenelope Mei Yu Or
Nov 4, 2006·The EMBO Journal·Naoya OnoharaHitoshi Kurose
Dec 19, 2006·Journal of Molecular and Cellular Cardiology·Takayoshi OhbaHiroshi Ito
Jan 25, 2007·Basic & Clinical Pharmacology & Toxicology·Zhi-Ming WuHao Wu
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Dan ShanJohn C Chatham
Oct 3, 2009·Circulation Research·Malini SethPaul Rosenberg
Mar 17, 2010·Neuroscience Letters·Hong-Ning ZhangXiao-Ping Pu
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xu WuJeffery D Molkentin
Jul 24, 2010·Journal of Cardiovascular Translational Research·Janelle RowellDavid A Kass
Aug 9, 2011·Journal of Molecular and Cellular Cardiology·Can M SagLars S Maier
Sep 20, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanhui WangDe-an Guo
Dec 6, 2012·Nature Communications·Jian XieChou-Long Huang
Mar 16, 2013·Medicinal Research Reviews·Filipa S CarvalhoPaulo J Oliveira
May 4, 2013·Toxicology·Balindiwe J N SishiAnna-Mart Engelbrecht
Jul 16, 2013·Biochimica Et Biophysica Acta·Renata Sano, John C Reed
Sep 10, 2013·Biochemical and Biophysical Research Communications·Joo Hee LeeDo Han Kim
Jan 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kinya SeoDavid A Kass
Mar 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Masayuki KoyamaTetsuji Miura

❮ Previous
Next ❯

Citations

Aug 28, 2018·Oxidative Medicine and Cellular Longevity·Javier PalaciosFredi Cifuentes
Jul 18, 2020·Clinical Science·Keith DadsonFilio Billia
Dec 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh YarmohammadiGholamreza Karimi
Dec 22, 2020·Frontiers in Pharmacology·Zhun XiaoPing Liu
Feb 1, 2020·Pharmacology & Therapeutics·Hongbo WangMichael X Zhu
Jul 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cun LiuChanggang Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.