Abstract
Stem cells hold great promise for brain and spinal cord injuries (SCI), but cell survival following transplantation to adult central nervous system has been poor. Salvianolic acid B (Sal B) has been shown to improve functional recovery in brain-injured rats. The present study was designed to determine whether Sal B could improve transplanted mesenchymal stem cell (MSC) survival in SCI rats. SCI rats were treated with Sal B. The Basso-Beatie-Bresnahan (BBB) scale was used to test the functional recovery. Sal B was used to protect MSC from being damaged by TNF-alpha in vitro. Bromodeoxyuridine-labeled MSC were transplanted into SCI rats with Sal B intraperitoneal injection, simultaneously. MSC were examined, and the functional recovery of the SCI rats was tested. Sal B treatment significantly reduced the lesion area from 0.26+/-0.05 mm2 to 0.15+/-0.03 mm2 (P<0.01) and remarkably raised the BBB scores on d 28, post-injury, from 7.3+/-0.9 to 10.5+/-1.3 (P<0.05), compared with the phosphate-buffered saline (PBS) control group. MSC were protected from the damage of TNF-alpha by Sal B. The number of surviving MSC in the MSC plus Sal B groups were 1143.3+/-195.6 and 764.0+/-81.3 on d 7 and 28, post-transplantation, more than those in t...Continue Reading
References
Oct 1, 1991·The Journal of Clinical Investigation·M S MulliganP A Ward
Jan 1, 1986·The American Journal of Chinese Medicine·X L Lei, G C Chiou
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Feb 1, 1996·Experimental Neurology·C N SvendsenS B Dunnett
Aug 1, 1997·Journal of Neurotrauma·E A ZompaC E Hulsebosch
May 19, 1998·Annals of Neurology·D W PincusS A Goldman
Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Jul 23, 1999·Brain Pathology·A L Vescovi, E Y Snyder
Oct 8, 1999·Journal of Neurotrauma·K I ParkE Y Snyder
Sep 20, 2000·Experimental Neurology·R A Fricker-GatesA Björklund
Mar 17, 2001·Journal of Asian Natural Products Research·G H DuJ T Zhang
Aug 14, 2001·Journal of Cellular Biochemistry·Y H ChenY L Chen
Oct 29, 2003·Neurosurgery·Daisuke TsuchiyaPhilip R Weinstein
Dec 31, 2003·The Journal of Surgical Research·Ing-Shiow LayChew-Wun Wu
Jul 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Noritoshi NagayaSoichiro Kitamura
Jun 24, 2006·Cytotherapy·Y-B DengG-Q Zhou
Jul 29, 2006·Stem Cells·Thomas M CoyneIra B Black
Aug 31, 2006·Behavioural Pharmacology·Minke TangJuntian Zhang
Sep 9, 2006·Journal of Neurotrauma·Lucia UrdzíkováEva Syková
Citations
Aug 16, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hajime InoueNorio Kumagai
Feb 12, 2010·Journal of Neurotrauma·Wolfram TetzlaffBrian K Kwon
May 27, 2010·Cancer Prevention Research·Yuan ZhaoXinbin Gu
Feb 27, 2014·Journal of Ethnopharmacology·Tao ShuXuan Wang
Sep 6, 2014·International Journal of Cardiology·Hai-Dong GuoShui-Jin Shao
Jan 19, 2016·Neuroscience Letters·Zhihui DongGang Yao
Sep 4, 2015·Biological & Pharmaceutical Bulletin·Liang KongJingxian Yang
Apr 17, 2009·Brain Research·Jingwei TianShumin Zhang
Apr 11, 2015·Pharmaceutical Biology·Xiu-Zhen ZhangRui-Qi Wang
Mar 23, 2011·Brain Research·Yu LiuQi-Yong Gong
May 19, 2012·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Jian-Wen GuoBen Li
Jan 6, 2015·Acta Biomaterialia·Marie-Sophie QuittetMyriam Bernaudin
Oct 23, 2012·European Journal of Pharmacology·Nan ZhangJingxian Yang
Jan 21, 2014·Journal of Pharmacological Sciences·Zhong GaoSafeng Zou
Apr 10, 2015·Neurochemical Research·Tao ShuBin Liu
Sep 10, 2014·Journal of Neurotrauma·Abel Torres-EspínXavier Navarro
Jun 27, 2018·The Journal of Pharmacy and Pharmacology·Ran KimWoochul Chang
Apr 27, 2019·Connective Tissue Research·Hui-Shen YanPing Bo
Feb 6, 2020·Experimental and Therapeutic Medicine·Hongming ZhouYao Zhao
Jan 29, 2011·Chembiochem : a European Journal of Chemical Biology·Jia-Hong LuMin Li