Salvianolic acid B promotes survival of transplanted mesenchymal stem cells in spinal cord-injured rats

Acta Pharmacologica Sinica
Xiao-bin BiYa-zhu Wang

Abstract

Stem cells hold great promise for brain and spinal cord injuries (SCI), but cell survival following transplantation to adult central nervous system has been poor. Salvianolic acid B (Sal B) has been shown to improve functional recovery in brain-injured rats. The present study was designed to determine whether Sal B could improve transplanted mesenchymal stem cell (MSC) survival in SCI rats. SCI rats were treated with Sal B. The Basso-Beatie-Bresnahan (BBB) scale was used to test the functional recovery. Sal B was used to protect MSC from being damaged by TNF-alpha in vitro. Bromodeoxyuridine-labeled MSC were transplanted into SCI rats with Sal B intraperitoneal injection, simultaneously. MSC were examined, and the functional recovery of the SCI rats was tested. Sal B treatment significantly reduced the lesion area from 0.26+/-0.05 mm2 to 0.15+/-0.03 mm2 (P<0.01) and remarkably raised the BBB scores on d 28, post-injury, from 7.3+/-0.9 to 10.5+/-1.3 (P<0.05), compared with the phosphate-buffered saline (PBS) control group. MSC were protected from the damage of TNF-alpha by Sal B. The number of surviving MSC in the MSC plus Sal B groups were 1143.3+/-195.6 and 764.0+/-81.3 on d 7 and 28, post-transplantation, more than those in t...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Investigation·M S MulliganP A Ward
Jan 1, 1986·The American Journal of Chinese Medicine·X L Lei, G C Chiou
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Aug 1, 1997·Journal of Neurotrauma·E A ZompaC E Hulsebosch
Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Mar 17, 2001·Journal of Asian Natural Products Research·G H DuJ T Zhang
Dec 31, 2003·The Journal of Surgical Research·Ing-Shiow LayChew-Wun Wu
Jul 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Noritoshi NagayaSoichiro Kitamura
Aug 31, 2006·Behavioural Pharmacology·Minke TangJuntian Zhang

❮ Previous
Next ❯

Citations

Aug 16, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hajime InoueNorio Kumagai
Feb 12, 2010·Journal of Neurotrauma·Wolfram TetzlaffBrian K Kwon
Feb 27, 2014·Journal of Ethnopharmacology·Tao ShuXuan Wang
Jan 19, 2016·Neuroscience Letters·Zhihui DongGang Yao
Apr 11, 2015·Pharmaceutical Biology·Xiu-Zhen ZhangRui-Qi Wang
Jun 27, 2018·The Journal of Pharmacy and Pharmacology·Ran KimWoochul Chang
Feb 6, 2020·Experimental and Therapeutic Medicine·Hongming ZhouYao Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.