Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A

Journal of Natural Products
Thomas A Munro, Mark A Rizzacasa

Abstract

Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).

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Citations

Dec 10, 2013·Journal of Ethnopharmacology·Ivan CasselmanMichael Heinrich
May 15, 2008·Chemical Reviews·Thomas E Prisinzano, Richard B Rothman
Sep 13, 2012·Chemical Reviews·Yi-Bing WuBin Cong
Jan 22, 2005·Journal of Medicinal Chemistry·Thomas A MunroFeng Yan
Apr 4, 2013·Journal of Medicinal Chemistry·Thomas E Prisinzano
Nov 19, 2005·The Journal of Organic Chemistry·Thomas A MunroMark A Rizzacasa
Aug 31, 2013·Journal of Natural Products·Madan Kumar PaudelSatoshi Morimoto
Jul 1, 2005·Organic Letters·Wayne W HardingThomas E Prisinzano
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Oct 11, 2005·Life Sciences·Thomas E Prisinzano
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