PMID: 6412615Jul 1, 1983Paper

Sample collection and processing for the assay of plasma renin activity. A comparison of anticoagulants and inhibitors

Annals of Clinical Biochemistry
J E RoulstonA L Muir

Abstract

Plasma renin activity was measured in samples collected in lithium heparin, sodium heparin, and ethylenediaminetetraacetate. The samples were incubated under two widely used sets of conditions to generate angiotensin I, and the results were compared. Under certain incubation conditions, the absence of ethylenediaminetetraacetate from the sample tube produced low plasma renin activity values. This was obviated by using an alternative incubation medium and was not, therefore, due to direct inhibition of renin by heparin. These lower values were not seen in samples from patients receiving captopril. This suggests that the discrepant values were due to some angiotensin I conversion to angiotensin II and lower homologues in the incubates. Sodium heparin samples compared closely with lithium heparin samples, indicating that the presence of lithium is not significant. These results show that, provided the incubation conditions are suitably modified, samples collected into lithium or sodium heparin can be used for measurement of plasma renin activity.

References

Aug 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E Roulston, G A MacGregor
Jan 1, 1978·Nephron·P C ChurchillF D McDonald
Feb 19, 1972·Lancet·E E KritzingerJ J Jones
Jun 3, 1972·Lancet·J R StockigtE G Biglieri
May 1, 1967·The Journal of Clinical Endocrinology and Metabolism·J E SealeyJ H Laragh
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Apr 1, 1972·Kidney International·J E SealeyJ H Laragh
Jul 1, 1981·Pathology·J R Stockigt, M J Hewett

❮ Previous
Next ❯

Citations

Jan 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·C G WathenJ E Roulston
Nov 1, 1983·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·J E RoulstonC G Wathen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.