PMID: 2490115Jan 1, 1989Paper

Sample preparation for the HPLC analysis of drugs in biological fluids

Journal of Pharmaceutical and Biomedical Analysis
R D McDowallV S Picot

Abstract

Sample preparation for the analysis of drugs in biological fluids consists of a number of unit operations that are used for (i) release of the drug from a conjugate or biological matrix; (ii) removal of endogenous compounds that could interfere with the assay; and (iii) techniques for liquid handling. The trends in sample preparation that have occurred over the past 10 years in the authors' laboratory are discussed. In general, there has been a move from the traditional liquid-liquid extraction to methods using bonded-silica which permit rapid throughput and efficient extraction. Automation of sample preparation has seen further gains in productivity; however, the present generation of equipment lack the control and communication systems that are essential for the development of the automated integrated laboratory of the future.

References

Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·R D McDowallG S Murkitt
Jan 1, 1985·Journal of Pharmaceutical and Biomedical Analysis·D A BarrettR M Lee

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Citations

Dec 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·B J GurleyD Skelton
Oct 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·D BonazziV Cavrini
Aug 1, 1994·Scandinavian Journal of Gastroenterology·K BorchJ F Rehfeld
Dec 14, 1999·British Journal of Clinical Pharmacology·S KechagiasA W Jones

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