Sample size calculation for the weighted rank statistics with paired survival data

Statistics in Medicine
Sin-Ho Jung

Abstract

This paper introduces a sample size calculation method for the weighted rank test statistics with paired two-sample survival data. Our sample size formula requires specification of joint survival and censoring distributions. For modelling the distribution of paired survival variables, we may use a paired exponential survival distribution that is specified by the marginal hazard rates and a measure of dependency. Also, in most trials randomizing paired subjects, the subjects of each pair are accrued and censored at the same time over an accrual period and an additional follow-up period, so that the paired subjects have a common censoring time. Under these practical settings, the design parameters include type I and type II error probabilities, marginal hazard rates under the alternative hypothesis, correlation coefficient, accrual period (or accrual rate) and follow-up period. If pilot data are available, we may estimate the survival distributions from them, but we specify the censoring distribution based on the specified accrual trend and the follow-up period planned for the new study. Through simulations, the formula is shown to provide accurate sample sizes under practical settings. Real studies are taken to demonstrate the p...Continue Reading

Citations

Feb 26, 2014·Computational Statistics & Data Analysis·Pei-Fang SuYu Shyr
Feb 27, 2013·Journal of Biopharmaceutical Statistics·Huan JinDongsheng Tu
Mar 1, 2018·Statistical Methods in Medical Research·Chi-Chung Wen, Yi-Hau Chen
Jun 26, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Nicola J NelsonAnna L Carter
Jan 26, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Ronny BruffaertsMatthew K Nock
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams
Oct 20, 2012·Pharmaceutical Statistics·Toshimitsu HamasakiTakashi Sozu
Jan 20, 2021·Statistics in Medicine·Jianghao Li, Sin-Ho Jung
Oct 31, 2021·Lifetime Data Analysis·Jianghao Li, Sin-Ho Jung

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