Sample size calculations for comparing two groups of count data

Journal of Biopharmaceutical Statistics
Lin Wang, Chunpeng Fan

Abstract

A sample size formula for comparing two groups of count data is derived using the method of moments by matching the first and second moments of the distribution of the count data, and it does not need any further distributional assumption. Compared to sample size formulas derived using a likelihood-based approach or using simulations, the proposed sample size formula applies to count data following any distribution in addition to the negative binomial distribution. The proposed sample size formula can be used even when the study is analyzed with a likelihood-based approach. Because asymptotically, the method of moments is no more efficient than likelihood-based approaches, the proposed sample size formula can be viewed as an upper bound of the required sample size by likelihood-based approaches to start the study. Applications of the sample size formula are illustrated using an asthma study design.

References

Jan 30, 2009·Computational Statistics & Data Analysis·Inmaculada B AbanNsoki Mavinga
Jan 19, 2012·Journal of Biopharmaceutical Statistics·Mallik Rettiganti, H N Nagaraja
Sep 17, 2013·Statistics in Medicine·Haiyuan Zhu, Hassan Lakkis

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